Gogebashvili N V, Nonikashvili M I
Probl Tuberk. 1989(4):43-5.
Functional activity of peripheral blood NK-cells was studied in 85 patients aged 18 to 72 years with active destructive tuberculosis of the lungs. There was detected a significant decrease in the activity of the NK-cells them. The most pronounced decrease was observed in the patients over 50 years. The changes in the functional activity of the NK-cells during chemotherapy correlated with the time course of the tuberculosis process. The results of the study provided the use of the NK-cell activity index in addition to the other indices in estimation of the patients immunity status and control of the treatment efficacy. For correction of immunodeficiency detected by the NK-cell activity early use of immunostimulating agents in the combined therapy of the patients with destructive tuberculosis of the lungs was required.
对85名年龄在18至72岁之间患有活动性肺部破坏性肺结核的患者外周血自然杀伤细胞（NK细胞）的功能活性进行了研究。发现这些患者NK细胞的活性显著降低。50岁以上的患者中这种降低最为明显。化疗期间NK细胞功能活性的变化与结核病进程的时间过程相关。该研究结果表明，除了其他指标外，NK细胞活性指数可用于评估患者的免疫状态和控制治疗效果。为纠正通过NK细胞活性检测到的免疫缺陷，在患有肺部破坏性肺结核患者的联合治疗中需要尽早使用免疫刺激剂。
