Wang Bin, Liu Yingying, Li Zhenjiang, Li Zhiwen
Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
Environ Pollut. 2016 Sep;216:646-652. doi: 10.1016/j.envpol.2016.06.026. Epub 2016 Jun 22.
An association of influenza-like illness (ILI) with outdoor air pollution has been reported. However, the effect of indoor air pollution on ILI was rarely investigated. We aimed to determine an association of indoor air pollution from coal combustion (IAPCC) and lifestyle with ILI risk in housewives, and the modification effect of phase II metabolic enzyme genes. We recruited 403 housewives for a cross-sectional study in Shanxi Province, China, including 135 with ILI frequency (≥1 time per year in the past ten years) as the case group and 268 with ILI frequency (<1 times per year) as the control group. Information on their energy usage characteristics and lifestyle was collected by questionnaires, as well as the single nucleotide polymorphisms (SNPs) of epoxide hydrolase 1 (rs1051740 and rs2234922), N-acetyltransferase 2 (rs1041983), and glutathione S-transferase (rs1695). We used exposure index to indicate the level of IAPCC among housewives. Our results revealed that the exposure index was positively correlated with ILI frequency. A significant dose-response trend between the exposure index and ILI risk was found with or without adjusting for confounders. Cooking frequency in kitchen with coal as primary fuel and ventilation frequency in the living room or bedroom with a coal-fueled stove for heating during the heating season were two important risk factors to affect ILI frequency. Only rs1051740 was found to be associated with exposure index, whereas it didn't have interaction effect with exposure index on ILI frequency. In conclusion, IAPCC and SNPs of rs1051740 were both associated with ILI frequency.
已有报告称流感样疾病（ILI）与室外空气污染有关联。然而，室内空气污染对ILI的影响却鲜有研究。我们旨在确定家庭主妇中燃煤所致室内空气污染（IAPCC）及生活方式与ILI风险之间的关联，以及II期代谢酶基因的修饰作用。我们在中国山西省招募了403名家庭主妇进行一项横断面研究，其中135名ILI发病频率（过去十年中每年≥1次）的妇女作为病例组，268名ILI发病频率（每年<1次）的妇女作为对照组。通过问卷调查收集她们的能源使用特征和生活方式信息，以及环氧水解酶1（rs1051740和rs2234922）、N-乙酰转移酶2（rs1041983）和谷胱甘肽S-转移酶（rs1695）的单核苷酸多态性（SNP）。我们用暴露指数来表示家庭主妇中IAPCC的水平。我们的结果显示暴露指数与ILI发病频率呈正相关。无论是否对混杂因素进行校正，暴露指数与ILI风险之间均存在显著的剂量反应趋势。以煤为主要燃料的厨房烹饪频率以及供暖季节使用燃煤炉灶供暖的客厅或卧室的通风频率是影响ILI发病频率的两个重要危险因素。仅发现rs1051740与暴露指数有关联，而它在ILI发病频率上与暴露指数没有交互作用。总之，IAPCC和rs1051740的SNP均与ILI发病频率有关。
