Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing, 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, PR China.
Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, 100191, PR China.
Ecotoxicol Environ Saf. 2020 May;194:110405. doi: 10.1016/j.ecoenv.2020.110405. Epub 2020 Mar 9.
The association between environmental pollution and risk of influenza-like illness (ILI) among general population has been reported. However, the relationships between the individual pollutants and ILI risk are still under discussion. Our study aimed to explore the associations of the typical environmental polycyclic aromatic hydrocarbons (PAHs) and metal(loid)s with ILI risk among women population. We carried out a cross-sectional study and included a total of 396 housewives in Shanxi Province, China. The information on their general characteristics and ILI frequency was collected by questionnaire. We collected their hair samples and analyzed the concentrations of PAHs and various metal(loid)s. The results indicated that only acenaphthylene concentration of the nine detected PAH congeners in the hair was significantly associated with ILI risk with adjusted odds ratio (AOR) and 95% confidence interval (95% CI) of 0.58 (0.38 - 0.91). Among the concerned 4 toxic metal(loid)s and 15 rare earth elements, only the hair concentration of arsenic had a positive dose-response relationship with ILI risk. In addition, we found that there were negative dose-response associations of the three essential trace elements (i.e. chromium, cobalt, and nickel), and four essential alkaline earth elements (i.e. magnesium, calcium, strontium, barium) with ILI risk. It was concluded that the environmental exposure to certain compounds of housewives may contribute to their ILI development.
已有研究报道，环境污染与普通人群患流感样疾病（ILI）的风险之间存在关联。然而，个别污染物与 ILI 风险之间的关系仍存在争议。本研究旨在探讨典型环境多环芳烃（PAHs）和金属（类）与女性人群 ILI 风险之间的关系。我们进行了一项横断面研究，共纳入山西省 396 名家庭主妇。通过问卷调查收集了她们的一般特征和 ILI 频率信息。我们采集了她们的头发样本，并分析了 PAHs 和各种金属（类）的浓度。结果表明，头发中检测到的 9 种 PAH 同系物中只有苊烯浓度与 ILI 风险显著相关，调整后的比值比（AOR）和 95%置信区间（95%CI）为 0.58（0.38-0.91）。在所关注的 4 种有毒金属（类）和 15 种稀土元素中，只有砷的头发浓度与 ILI 风险呈正剂量反应关系。此外，我们发现，三种必需微量元素（即铬、钴和镍）和四种必需碱性土金属（即镁、钙、锶、钡）与 ILI 风险之间存在负剂量反应关系。综上所述，家庭主妇环境暴露于某些化合物可能会导致她们患 ILI。
