Papillon Julien P N, Pan Meihui, Brousseau Margaret E, Gilchrist Mark A, Lou Changgang, Singh Alok K, Stawicki Todd, Thompson James E
Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Cardiovascular and Metabolism, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, United States.
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3514-7. doi: 10.1016/j.bmcl.2016.06.032. Epub 2016 Jun 14.
We designed and prepared synthetic phospholipids that generate lyso-phosphatidylcholine products with a unique mass for convenient detection by LC-MS in complex biological matrices. We demonstrated that compound 4, formulated either as a Triton X-100 emulsion or incorporated in synthetic HDL particles can serve as a substrate for plasma EL with useful specificity.
