小米蛋白水解物对自发性高血压大鼠降压作用的研究。
Effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats.
机构信息
College of Food Science and Nutritional Engineering, China Agricultural University, 17 Tsinghua East Road, Beijing, 100083, China.
National Engineering Research Center for Fruits and Vegetables Processing, 17 Tsinghua East Road, Beijing, 100083, China.
出版信息
Eur J Nutr. 2017 Sep;56(6):2129-2138. doi: 10.1007/s00394-016-1252-7. Epub 2016 Jun 25.
PURPOSE
The objective of this study was to determine the effect of foxtail millet protein hydrolysates on lowering blood pressure in spontaneously hypertensive rats (SHRs).
METHODS
The protein of foxtail millet after extruding or fermenting and the raw foxtail millet was extracted and hydrolyzed by digestive protease to generate angiotensin-converting enzyme (ACE) inhibitory peptides. The potential antihypertensive effect of protein hydrolysates from foxtail millet in SHRs was investigated.
RESULTS
After 4 weeks of treatment with 200 mg peptides/kg of body weight of protein hydrolysates, blood pressure was lowered significantly, and the raw and extruded samples were more effective than the fermented samples. The serum ACE activity and angiotensin II levels in the treatment groups were significantly lower than that of the control. The percent heart weight decreased in the treatment groups.
CONCLUSION
Thus, ingestion of foxtail millet protein hydrolysates especially for the raw and extruded hydrolysates may ameliorate hypertension and alleviate related cardiovascular diseases.
目的
本研究旨在确定黍蛋白水解物对自发性高血压大鼠（SHR）降血压的作用。
方法
挤压或发酵后的黍米蛋白和原黍米经消化蛋白酶提取并水解生成血管紧张素转化酶（ACE）抑制肽。研究了黍蛋白水解物对 SHR 的潜在降压作用。
结果
经 4 周 200mg/kg 体重的肽处理后，血压显著降低，且原样品和挤压样品比发酵样品更有效。治疗组的血清 ACE 活性和血管紧张素 II 水平明显低于对照组。治疗组的心脏重量百分比降低。
结论
因此，摄入黍米蛋白水解物，特别是原样品和挤压样品的水解物，可能改善高血压并缓解相关心血管疾病。
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