Yamamoto H, Bando S, Nishikado A, Nishimura N, Akiyama K, Nouzu N, Mori H
Kokyu To Junkan. 1989 Jan;37(1):77-81.
Electrophysiological studies were performed to evaluate the effects of MgSO4 on human conduction system. Nine patients who received 20 mg/kg of MgSO4 did not show any significant changes in the electrophysiological parameters except for prolongations in the PR and AH intervals. After the infusion of 40 mg/kg of MgSO4 in eleven patients, sinus cycle length and corrected sinus node recovery time were increased but statistically insignificantly. Sinoatrial conduction time, the PR interval and AH interval were increased. The effective refractory period (ERP) of right atrium, ERP of atrioventricular node (AV node), ERP of right ventricule and ERP/QTc were increased significantly. These findings suggests that the antiarrhythmic effects of magnesium were due to (1) suppression of the functions of the sinus and AV nodes, and (2) shortening of the duration of the ventricular vulnerable period during the cardiac cycle and prevention of ventricular arrhythmias related reentry mechanism.
进行电生理研究以评估硫酸镁对人体传导系统的影响。9名接受20mg/kg硫酸镁的患者，除PR和AH间期延长外，电生理参数未显示任何显著变化。11名患者输注40mg/kg硫酸镁后，窦性周期长度和校正窦房结恢复时间增加，但无统计学意义。窦房传导时间、PR间期和AH间期增加。右心房有效不应期（ERP）、房室结（AV结）ERP、右心室ERP和ERP/QTc显著增加。这些发现表明，镁的抗心律失常作用归因于：（1）抑制窦房结和房室结功能；（2）缩短心动周期中心室易损期的持续时间，并预防与折返机制相关的室性心律失常。
