Kaviani Sanaz, Zeraatkar Navid, Sajedi Salar, Akbarzadeh Afshin, Gorjizadeh Nahid, Farahani Mohammad Hossein, Teimourian Behnoosh, Ghafarian Pardis, Sabet Hamid, Ay Mohammad Reza
Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.
Phys Med. 2016 Jul;32(7):889-97. doi: 10.1016/j.ejmp.2016.06.004. Epub 2016 Jun 23.
We developed a high performance portable gamma camera platform dedicated to identification of sentinel lymph nodes (SLNs) and radio-guided surgery for cancer patients. In this work, we present the performance characteristics of SURGEOSIGHT-I, the first version of this platform that can intra-operatively provide high-resolution images of the surveyed areas.
At the heart of this camera, there is a 43×43 array of pixelated sodium-activated cesium iodide (CsI(Na)) scintillation crystal with 1×1mm(2) pixel size and 5mm thickness coupled to a Hamamatsu H8500 flat-panel multi-anode (64 channels) photomultiplier tube. The probe is equipped with a hexagonal parallel-hole lead collimator with 1.2mm holes. The detector, collimator, and the associated front-end electronics are encapsulated in a common housing referred to as head.
Our results show a count rate of ∼41kcps for 20% count loss. The extrinsic energy resolution was measured as 20.6% at 140keV. The spatial resolution and the sensitivity of the system on the collimator surface was measured as 2.2mm and 142cps/MBq, respectively. In addition, the integral and differential uniformity, after uniformity correction, in useful field-of-view (UFOV) were measured 4.5% and 4.6%, respectively.
This system can be used for a number of clinical applications including SLN biopsy and radiopharmaceutical-guided surgery.
我们开发了一种高性能便携式γ相机平台，专门用于识别癌症患者的前哨淋巴结（SLN）并进行放射性引导手术。在这项工作中，我们展示了SURGEOSIGHT - I的性能特征，这是该平台的第一个版本，能够在术中提供被检查区域的高分辨率图像。
该相机的核心是一个43×43阵列的像素化碘化钠激活铯（CsI(Na)）闪烁晶体，像素尺寸为1×1mm²，厚度为5mm，与滨松H8500平板多阳极（64通道）光电倍增管耦合。探头配备有孔直径为1.2mm的六边形平行孔铅准直器。探测器、准直器和相关的前端电子设备封装在一个称为头部的共同外壳中。
我们的结果显示，在计数损失20%时，计数率约为41kcps。在140keV下，外部能量分辨率测量为20.6%。系统在准直器表面的空间分辨率和灵敏度分别测量为2.2mm和142cps/MBq。此外，在均匀性校正后，有用视野（UFOV）内的积分均匀性和微分均匀性分别测量为4.5%和4.6%。
该系统可用于多种临床应用，包括SLN活检和放射性药物引导手术。
