Carreras O, Delgado M J, Murillo M L
Dept. of Animal Physiology, School of Pharmacy, University of Sevilla, Spain.
Scand J Gastroenterol. 1989 Apr;24(3):304-8. doi: 10.3109/00365528909093051.
In vivo D-galactose absorption by the whole intestine between duodenum and rectum was studied in rats 1 month after sham operation, 50% proximal resection, intestinal bypass, or 50% distal resection. The total serosal areas were evaluated by means of an integrative method, obtaining reduced surfaces in resected or bypassed animals as compared with controls. The rate of D-galactose absorption, measured within 10 min, increased after proximal resection and bypass and diminished after distal resection, although the level was similar to that of controls at higher substrate concentrations. When expressed as serosal area, results in proximal and bypassed animals were higher than in controls, without differences (at lower galactose concentrations), and increased (at 25 mM), after distal resection. The total absorptive capacity related to wet and dry weight showed no differences in proximal and bypassed groups and a decrease after distal resection. The above results confirm a good level of recuperation when proximal intestinal surface is excluded. In case of ileal extirpation, a smaller compensatory response was found, which would be compensated for by a high substrate concentration in the intestinal lumen.
在假手术、近端50%切除、肠旁路手术或远端50%切除术后1个月的大鼠中，研究了十二指肠至直肠之间的整个肠道对体内D-半乳糖的吸收情况。采用综合方法评估总浆膜面积，结果显示与对照组相比，切除或旁路手术动物的浆膜面积减小。在10分钟内测量的D-半乳糖吸收速率，在近端切除和旁路手术后增加，在远端切除后降低，尽管在较高底物浓度下其水平与对照组相似。以浆膜面积表示时，近端和旁路手术动物的结果高于对照组，在较低半乳糖浓度下无差异，在远端切除后（25 mM时）增加。与湿重和干重相关的总吸收能力在近端和旁路手术组中无差异，在远端切除后降低。上述结果证实，当排除近端肠表面时，恢复水平良好。在回肠切除的情况下，发现代偿反应较小，这将通过肠腔内高底物浓度得到补偿。
