Carreras O, Vazquez A L, Rubio J M, Delgado M J, Murillo M L
Departamento Fisiologia y Biologia Animal, Facultad de Farmacia, Universidad de Sevilla, Spain.
Alcohol. 1992 Jan-Feb;9(1):83-6. doi: 10.1016/0741-8329(92)90015-3.
The in vivo absorption of D-galactose by rat whole intestinal surface after 4 weeks of 30% ethanol ingestion in drinking water has been studied, and the results were compared with ad lib-fed control rats. The total serosal intestinal area was determined by integration obtaining similar values between control and alcohol-treated groups. In the caecum surface of ethanol-fed rats slight but not significant increases were found, while the jejunum area decreased with respect to control rats. Total galactose absorption during 10 min of perfusion was slightly increased in ethanol-fed rats but these results were not significant with the substrate concentrations tested. When absorption data were referred to serosal surface, the absorption/cm2 values in ethanol-fed rats were increased at the studied galactose concentrations although these results were only statistically significant at 10 mM. In conclusion, the present data indicates a slight increase in D-galactose absorptive capacity by the whole intestine in ethanol-fed rats which suggest that the tissue traditionally not evaluated such as caecum and colon could modify the functional response to the absorption nutrients.
研究了饮用含30%乙醇的水4周后大鼠全肠表面对D-半乳糖的体内吸收情况，并将结果与自由进食的对照大鼠进行了比较。通过积分确定总浆膜肠面积，对照组和酒精处理组之间获得了相似的值。在乙醇喂养大鼠的盲肠表面发现有轻微但不显著的增加，而空肠面积相对于对照大鼠有所减少。在灌注10分钟期间，乙醇喂养大鼠的总半乳糖吸收略有增加，但这些结果在所测试的底物浓度下并不显著。当将吸收数据参考浆膜表面时，在研究的半乳糖浓度下，乙醇喂养大鼠的吸收/cm²值有所增加，尽管这些结果仅在10 mM时具有统计学意义。总之，目前的数据表明乙醇喂养大鼠的全肠对D-半乳糖的吸收能力略有增加，这表明传统上未评估的组织如盲肠和结肠可能会改变对营养吸收的功能反应。
