German S V, Lemeshko Z A, Vaĭnshteĭn T Ia, Petrova E A
Sov Med. 1989(3):15-9.
Bile excretion and biochemical properties of bile were investigated in 86 patients with the endogenic hypercorticism syndrome, 78 patients with the Itsenko-Cushing disease and in 8 patients with corticosteroma. A considerable incidence of functional and organic biliary disorders was demonstrated. Changes in cholecyst contractility were recorded in 54.6% of the patients, with hypermotor dyskinesia (36.4%) prevailing. An excess of endogenic corticosteroids was frequently accompanied by a hypotonus of Oddi's sphincter (65.6%) or Lutkens' sphincter (67.2%). Chronic (stoneless) cholecystitis was diagnosed in 70.9% of the patients, cholelithiasis, in 16.3%, and cholecyst cholesterosis, in 3.5%. Adrenocortical hyperfunction was associated with natural changes in biochemical composition of the bile, such as excessive cholesterol and a relative deficiency of cholic acid and phospholipids which might be conducive to cholelithiasis. High incidence of biliary disturbances and their pattern should be taken into account in the treatment of patients with hypercorticism.
对86例库欣综合征患者、78例库欣病患者及8例肾上腺皮质瘤患者的胆汁排泄及胆汁生化特性进行了研究。结果显示，功能性和器质性胆道疾病的发生率相当高。54.6%的患者记录到胆囊收缩功能改变，其中以运动亢进性运动障碍（36.4%）为主。内源性皮质类固醇过多常伴有奥迪括约肌（65.6%）或卢特肯斯括约肌（67.2%）张力降低。70.9%的患者诊断为慢性（无结石）胆囊炎，16.3%为胆石症，3.5%为胆囊胆固醇沉着症。肾上腺皮质功能亢进与胆汁生化成分的自然变化有关，如胆固醇过多、胆酸和磷脂相对缺乏，这可能有利于胆石症的发生。在库欣综合征患者的治疗中，应考虑到胆道疾病的高发生率及其模式。
