German S V, Vinnitskiĭ L I
Klin Med (Mosk). 1989 Jun;67(6):36-40.
Basal immunoreactive serum trypsin (RIT) was determined in comparative study of 46 patients with adrenocortical hyperfunction and 24 patients with hypocorticism for specifying the potentialities of the diagnostic test. Excess of endogenous corticosteroids is accompanied by a marked increase in the RIT serum concentration, this increase is particularly pronounced in Itsenko-Cushing syndrome and in exacerbations of Itsenko-Cushing disease in comparison with its level in Itsenko-Cushing disease remission. The presence of steroid diabetes had no significant RIT changes in Itsenko-Cushing disease. Attendant chronic pancreatitis that developed in patients with adrenocortical hyperfunction had no influence on blood serum RIT content. In patients with adrenal steroid deficiency who did not take glucocorticoids the serum RIT concentration was lower than that in those who constantly used hormones. RIT is increased in cases of chronic pancreatitis combined with chronic adrenal insufficiency. Measurement of the basal serum RIT may contribute to the diagnosis of pancreatitis in patients with hypocorticism but provides no information on this pathology in patients with endogenous hypercorticism.
在一项针对46例肾上腺皮质功能亢进患者和24例肾上腺皮质功能减退患者的对比研究中，测定了基础免疫反应性血清胰蛋白酶（RIT），以明确该诊断检测的潜力。内源性皮质类固醇过多会伴随RIT血清浓度显著升高，与艾迪生病缓解期的水平相比，这种升高在库欣综合征以及艾迪生病发作期尤为明显。在艾迪生病中，类固醇糖尿病的存在并未使RIT发生显著变化。肾上腺皮质功能亢进患者并发的慢性胰腺炎对血清RIT含量无影响。未服用糖皮质激素的肾上腺类固醇缺乏患者，其血清RIT浓度低于持续使用激素的患者。慢性胰腺炎合并慢性肾上腺功能不全时RIT会升高。测定基础血清RIT可能有助于肾上腺皮质功能减退患者胰腺炎的诊断，但对于内源性皮质功能亢进患者的该种病理情况并无诊断价值。
