Ellinger Sabine
Faculty of Food, Nutrition and Hospitality Sciences, Hochschule Niederrhein, University of Applied Sciences, Mönchengladbach, Germany.
Curr Opin Clin Nutr Metab Care. 2016 Sep;19(5):371-376. doi: 10.1097/MCO.0000000000000303.
The purpose of review is to provide an overview on specific nutrients which play an important role in bowel wound healing, and to judge the efficacy of supplementation to derive recommendations for clinical practice.
Glutamine, arginine, butyrate, ω-3 fatty acids, nucleotides, and several micronutrients are involved in bowel wound healing. However, with regard to clinical trials, the efficacy of supplementation of specific nutrients on bowel wound healing in patients with inflammatory bowel diseases has not been clarified yet. In patients undergoing colon surgery, sufficient evidence exists that the perioperative supply of an enteral immunomodulating formula enriched with arginine, nucleotides, and ω-3 fatty acids may improve intestinal wound healing, considering the lower risk of wound infections, wound dehiscence, and intra-abdominal abscess.
Even if a range of nutrients are involved in bowel wound healing, only perioperative supply of an enteral immunomodulating formula to cancer patients undergoing colon surgery, can be recommended. Further randomized controlled trials are needed to elucidate the efficacy of individual nutrients on intestinal wound healing.
本综述旨在概述在肠道伤口愈合中起重要作用的特定营养素，并评估补充这些营养素的疗效，从而为临床实践提供建议。
谷氨酰胺、精氨酸、丁酸盐、ω-3脂肪酸、核苷酸和几种微量营养素参与肠道伤口愈合。然而，就临床试验而言，补充特定营养素对炎症性肠病患者肠道伤口愈合的疗效尚未明确。在接受结肠手术的患者中，有充分证据表明，围手术期提供富含精氨酸、核苷酸和ω-3脂肪酸的肠内免疫调节配方可能会改善肠道伤口愈合，因为伤口感染、伤口裂开和腹腔内脓肿的风险较低。
即使多种营养素参与肠道伤口愈合，但目前仅建议对接受结肠手术的癌症患者围手术期提供肠内免疫调节配方。需要进一步的随机对照试验来阐明单一营养素对肠道伤口愈合的疗效。
