硫代菊苣素A，一种从细叶万寿菊中提取的新型细胞毒性噻吩。

Thiotagetin A, a new cytotoxic thiophene from Tagetes minuta.

作者信息

Ibrahim Sabrin R M, Mohamed Gamal A

机构信息

a Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy , Taibah University , Al Madinah Al Munawwarah , Saudi Arabia.

b Faculty of Pharmacy, Department of Pharmacognosy , Assiut University , Assiut , Egypt.

出版信息

Nat Prod Res. 2017 Mar;31(5):543-547. doi: 10.1080/14786419.2016.1201672. Epub 2016 Jun 27.

DOI:10.1080/14786419.2016.1201672

PMID:27348403

Abstract

Phytochemical investigation of the n-hexane fraction of the methanolic extract of Tagetes minuta L. (Asteraceae) aerial parts afforded a new thiophene derivative: thiotagetin A (3), together with β-sitosterol (1) and stigmasterol (2). The structure of the new thiophene was identified by UV, IR, 1D (H and C), 2D (H-H COSY, HSQC and HMBC) NMR and HRESIMS spectral data. Compound 3 displayed cytotoxic activity against KB and MCF7 cancer cell lines with ED values of 2.03 and 3.88 μg/mL, respectively, compared to adriamycin (0.26 and 0.07 μg/mL, respectively).

摘要

对万寿菊（菊科）地上部分甲醇提取物的正己烷馏分进行植物化学研究，得到一种新的噻吩衍生物：硫代万寿菊素A（3），以及β-谷甾醇（1）和豆甾醇（2）。通过紫外光谱、红外光谱、一维（氢和碳）、二维（氢-氢化学位移相关谱、异核单量子相干谱和异核多键相关谱）核磁共振谱和高分辨电喷雾电离质谱光谱数据确定了新噻吩的结构。与阿霉素（分别为0.26和0.07μg/mL）相比，化合物3对KB和MCF7癌细胞系显示出细胞毒性活性，其半数有效剂量分别为2.03和3.88μg/mL。