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Beta-blockers in septic shock to optimize hemodynamics? Yes.

作者信息

Reuter Daniel A, Russell James A, Mekontso Dessap Armand

机构信息

Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, Hamburg Eppendorf University Medical Center, Martinistr. 52, 20246, Hamburg, Germany.

Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

出版信息

Intensive Care Med. 2016 Oct;42(10):1607-1609. doi: 10.1007/s00134-016-4414-4. Epub 2016 Jun 27.

DOI:10.1007/s00134-016-4414-4
PMID:27349239
Abstract
摘要

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Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study.艾司洛尔降低心率与感染性休克患者动脉弹性改善相关：一项前瞻性观察研究。
Intensive Care Med. 2016 Oct;42(10):1528-1534. doi: 10.1007/s00134-016-4351-2. Epub 2016 Apr 21.
2
Combination therapy with milrinone and esmolol for heart protection in patients with severe sepsis: a prospective, randomized trial.米力农与艾司洛尔联合治疗对严重脓毒症患者的心脏保护作用：一项前瞻性随机试验。
Clin Drug Investig. 2015 Nov;35(11):707-16. doi: 10.1007/s40261-015-0325-3.
3
Infusion of esmolol attenuates lipopolysaccharide-induced myocardial dysfunction.
肥厚型心肌病伴动态腔隙梗阻时的心脏骤停：去儿茶酚胺策略的实例
J Intensive Care Soc. 2018 Feb;19(1):69-75. doi: 10.1177/1751143717732729. Epub 2017 Oct 9.
艾司洛尔输注可减轻脂多糖诱导的心肌功能障碍。
J Surg Res. 2016 Jan;200(1):283-9. doi: 10.1016/j.jss.2015.07.015. Epub 2015 Jul 14.
4
Beta-blocker use in severe sepsis and septic shock: a systematic review.β受体阻滞剂在严重脓毒症和脓毒性休克中的应用：一项系统评价
Curr Med Res Opin. 2015;31(10):1817-25. doi: 10.1185/03007995.2015.1062357. Epub 2015 Aug 20.
5
Esmolol: immunomodulator in pyelonephritis by Pseudomonas aeruginosa.依替米星：绿脓杆菌致肾盂肾炎的免疫调节剂。
J Surg Res. 2015 Sep;198(1):175-84. doi: 10.1016/j.jss.2015.05.026. Epub 2015 May 21.
6
β1-Adrenergic Inhibition Improves Cardiac and Vascular Function in Experimental Septic Shock.β1-肾上腺素能抑制改善实验性脓毒性休克的心功能和血管功能。
Crit Care Med. 2015 Sep;43(9):e332-40. doi: 10.1097/CCM.0000000000001078.
7
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.循环休克与血流动力学监测共识。欧洲重症监护医学学会特别工作组。
Intensive Care Med. 2014 Dec;40(12):1795-815. doi: 10.1007/s00134-014-3525-z. Epub 2014 Nov 13.
8
Inhibition of sepsis-induced inflammatory response by β1-adrenergic antagonists.β1-肾上腺素能拮抗剂抑制脓毒症引起的炎症反应。
J Trauma Acute Care Surg. 2014 Feb;76(2):320-7; discussion 327-8. doi: 10.1097/TA.0000000000000113.
9
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.艾司洛尔对感染性休克患者血流动力学和临床结局的影响：一项随机临床试验。
JAMA. 2013 Oct 23;310(16):1683-91. doi: 10.1001/jama.2013.278477.
10
Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study.脓毒性休克患者应用艾司洛尔控制心率的微血管效应：一项初步研究。
Crit Care Med. 2013 Sep;41(9):2162-8. doi: 10.1097/CCM.0b013e31828a678d.