Nielsen P A, Jøhncke H, Due E
Ugeskr Laeger. 1989 Jun 5;151(23):1470-2.
Thirty-eight permanent central venous catheters were introduced in 28 children as part of the intensive chemotherapeutic treatment for malignant disease. These catheters were employed partly for administration of medicine and partly for sampling blood for control. The total duration of life with a catheter was 7,303 days. On an average, 27 chemotherapeutic agents were administered, 172 supplementary injections and 56 blood samples were performed via the central venous catheter per child. In the present investigation, a frequency of infection of 0.27/100 catheter days was found and an incidence of non-infectious complications resulting in removal of the catheter or adjustment of the catheter of 0.16/100 catheter days. The authors consider that employment of a permanent central venous catheter in paediatric oncology represents considerable progress and that this should be employed in all children to be submitted to prolonged treatment with cancer chemotherapy.
作为恶性疾病强化化疗治疗的一部分，28名儿童共植入了38根永久性中心静脉导管。这些导管部分用于给药，部分用于采集血样进行检查。导管的总使用时长为7303天。平均每名儿童通过中心静脉导管给药27种化疗药物，进行172次辅助注射和采集56次血样。在本研究中，感染发生率为0.27/100导管日，导致导管拔除或调整的非感染性并发症发生率为0.16/100导管日。作者认为，在儿科肿瘤学中使用永久性中心静脉导管代表了相当大的进步，所有需要接受长期癌症化疗的儿童都应使用。
