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立体定向比较研究（18）F-Alfatide 和（18）F-FDG PET 成像在 LLC 荷瘤 C57BL/6 小鼠模型中的应用。

Stereotactic Comparison Study of (18)F-Alfatide and (18)F-FDG PET Imaging in an LLC Tumor-Bearing C57BL/6 Mouse Model.

机构信息

Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.

School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China.

出版信息

Sci Rep. 2016 Jun 28;6:28757. doi: 10.1038/srep28757.

DOI:10.1038/srep28757
PMID:27350554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4923897/
Abstract

This study aimed to stereotactically compare the PET imaging performance of (18)F-Alfatide ((18)F-ALF-NOTA-PRGD2, denoted as (18)F-Alfatide) and (18)F-fluorodeoxyglucose (FDG) and immunohistochemistry (IHC) staining in Lewis lung carcinoma (LLC) tumor-bearing C57BL/6 mouse model. (18)F-FDG standard uptake values (SUVs) were higher than (18)F-Alfatide SUVs in tumors, most of the normal tissues and organs except for the bladder. Tumor-to-brain, tumor-to-lung, and tumor-to-heart ratios of (18)F-Alfatide PET were significantly higher than those of (18)F-FDG PET (P < 0.001). The spatial heterogeneity of the tumors was detected, and the tracer accumulation enhanced from the outer layer to the inner layer consistently using the two tracers. The parameters of the tumors were significantly correlated with each other between (18)F-FDG SUV and GLUT-1 (R = 0.895, P < 0.001), (18)F-Alfatide SUV and αvβ3 (R = 0.595, P = 0.019), (18)F-FDG SUV and (18)F-Alfatide SUV (R = 0.917, P < 0.001), and GLUT-1 and αvβ3 (R = 0.637, P = 0.011). Therefore, (18)F-Alfatide PET may be an effective tracer for tumor detection, spatial heterogeneity imaging and an alternative supplement to (18)F-FDG PET, particularly for patients with enhanced characteristics in the brain, chest tumors or diabetes, meriting further study.

摘要

本研究旨在立体比较（18）F-阿法肽（（18）F-ALF-NOTA-PRGD2，记为（18）F-阿法肽）和（18）F-氟脱氧葡萄糖（FDG）的 PET 成像性能，并对 Lewis 肺癌（LLC）荷瘤 C57BL/6 小鼠模型进行免疫组织化学（IHC）染色。（18）F-FDG 标准摄取值（SUV）在肿瘤、大多数正常组织和器官（除膀胱外）均高于（18）F-阿法肽 SUV。（18）F-阿法肽 PET 的肿瘤与脑、肿瘤与肺和肿瘤与心脏的比值明显高于（18）F-FDG PET（P<0.001）。两种示踪剂均能检测到肿瘤的空间异质性，示踪剂的积聚从外层到内层逐渐增强。（18）F-FDG SUV 与 GLUT-1（R=0.895，P<0.001）、（18）F-阿法肽 SUV 与αvβ3（R=0.595，P=0.019）、（18）F-FDG SUV 与（18）F-阿法肽 SUV（R=0.917，P<0.001）以及 GLUT-1 与αvβ3（R=0.637，P=0.011）之间的肿瘤参数均呈显著相关。因此，（18）F-阿法肽 PET 可能是一种有效的肿瘤检测、空间异质性成像的示踪剂，可作为（18）F-FDG PET 的有效补充，特别是对脑、胸部肿瘤或糖尿病患者，值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/46c32bf6b5d0/srep28757-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/cfb7069c361a/srep28757-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/d0f6dd6c5bcf/srep28757-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/bcdc727671af/srep28757-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/a11b9ccc665b/srep28757-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/46c32bf6b5d0/srep28757-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/cfb7069c361a/srep28757-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/d0f6dd6c5bcf/srep28757-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/bcdc727671af/srep28757-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/a11b9ccc665b/srep28757-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ec3/4923897/46c32bf6b5d0/srep28757-f5.jpg

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