喷他脒和米替福新序贯用于治疗婴儿利什曼原虫-HIV合并感染
Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection.
作者信息
Faucher Jean-François, Morquin David, Reynes Jacques, Chirouze Catherine, Hoen Bruno, Le Moing Vincent
机构信息
Service des maladies infectieuses et Tropicales, CHRU de Besançon, 25030 Besançon cedex, France.
Service des maladies infectieuses et Tropicales, CHU de Montpellier, 34295 Montpellier cedex 5, France.
出版信息
Parasitol Int. 2016 Oct;65(5 Pt A):444-6. doi: 10.1016/j.parint.2016.06.009. Epub 2016 Jun 22.
Liposomal amphotericin B (LAmb) may fail to heal Leishmania infantum visceral leishmaniasis (VL) in the immunodeficient host. There are currently no guidelines on how to treat such patients and efficacy of miltefosine monotherapy seems limited in this indication. We present 2 cases of patients with VL and AIDS for which LAmb had to be interrupted (one because of toxicity, one because of treatment failure) and who were treated effectively with pentamidine followed by miltefosine.
脂质体两性霉素B（LAmb）可能无法治愈免疫缺陷宿主中的婴儿利什曼原虫内脏利什曼病（VL）。目前尚无关于如何治疗此类患者的指南，而在该适应症中，米替福新单药治疗的疗效似乎有限。我们报告2例VL合并艾滋病患者，其中1例因毒性反应、另1例因治疗失败而不得不中断LAmb治疗，随后用喷他脒继以米替福新治疗，均取得了有效疗效。
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