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精神病与抑郁症中的自我指涉:疾病的语言标志物。

Self-reference in psychosis and depression: a language marker of illness.

作者信息

Fineberg S K, Leavitt J, Deutsch-Link S, Dealy S, Landry C D, Pirruccio K, Shea S, Trent S, Cecchi G, Corlett P R

机构信息

Department of Psychiatry,Yale University,New Haven,CT,USA.

School of Medicine,Yale University,New Haven,CT,USA.

出版信息

Psychol Med. 2016 Sep;46(12):2605-15. doi: 10.1017/S0033291716001215. Epub 2016 Jun 29.

Abstract

BACKGROUND

Language use is of increasing interest in the study of mental illness. Analytical approaches range from phenomenological and qualitative to formal computational quantitative methods. Practically, the approach may have utility in predicting clinical outcomes. We harnessed a real-world sample (blog entries) from groups with psychosis, strong beliefs, odd beliefs, illness, mental illness and/or social isolation to validate and extend laboratory findings about lexical differences between psychosis and control subjects.

METHOD

We describe the results of two experiments using Linguistic Inquiry and Word Count software to assess word category frequencies. In experiment 1, we compared word use in psychosis and control subjects in the laboratory (23 per group), and related results to subject symptoms. In experiment 2, we examined lexical patterns in blog entries written by people with psychosis and eight comparison groups. In addition to between-group comparisons, we used factor analysis followed by clustering to discern the contributions of strong belief, odd belief and illness identity to lexical patterns.

RESULTS

Consistent with others' work, we found that first-person pronouns, biological process words and negative emotion words were more frequent in psychosis language. We tested lexical differences between bloggers with psychosis and multiple relevant comparison groups. Clustering analysis revealed that word use frequencies did not group individuals with strong or odd beliefs, but instead grouped individuals with any illness (mental or physical).

CONCLUSIONS

Pairing of laboratory and real-world samples reveals that lexical markers previously identified as specific language changes in depression and psychosis are probably markers of illness in general.

摘要

背景

语言使用在精神疾病研究中越来越受到关注。分析方法从现象学和定性方法到形式计算定量方法不等。实际上,该方法可能在预测临床结果方面具有实用性。我们利用来自患有精神病、坚定信念、怪异信念、疾病、精神疾病和/或社会隔离人群的真实样本(博客文章),来验证和扩展关于精神病患者与对照受试者之间词汇差异的实验室研究结果。

方法

我们描述了两项使用语言查询与字数统计软件来评估词类频率的实验结果。在实验1中,我们比较了实验室中精神病患者与对照受试者(每组23人)的用词情况,并将结果与受试者症状相关联。在实验2中,我们研究了患有精神病的人群以及八个比较组所写博客文章中的词汇模式。除了组间比较外,我们还使用因子分析,然后进行聚类分析,以辨别坚定信念、怪异信念和疾病身份对词汇模式的影响。

结果

与其他人的研究结果一致,我们发现第一人称代词、生物过程词和负面情绪词在精神病语言中出现得更为频繁。我们测试了患有精神病的博主与多个相关比较组之间的词汇差异。聚类分析表明,用词频率并没有将具有坚定或怪异信念的个体归为一类,而是将患有任何疾病(精神或身体疾病)的个体归为一类。

结论

实验室样本与真实世界样本的配对研究表明,先前被确定为抑郁症和精神病中特定语言变化的词汇标记,可能总体上是疾病的标记。

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