Qudrat Anam, Unni Netra
Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Canada.
Faculty of Applied Science and Engineering, University of Toronto, Toronto, Canada.
Yale J Biol Med. 2016 Jun 27;89(2):215-25. eCollection 2016 Jun.
Parkinson's disease is a late-onset neurodegenerative disease, characterized by both motor and non-motor symptoms. Motor symptoms include postural instability, rigidity, and tremor, while non-motor symptoms include anxiety, dementia, and depression. In this integrative review, we discuss PD disease pathophysiology in detail and introduce how neurotrophic growth factor delivery via a retroviral-based system can be used as efficacious tools for targeted gene therapy.
帕金森病是一种迟发性神经退行性疾病，其特征为运动症状和非运动症状。运动症状包括姿势不稳、僵硬和震颤，而非运动症状包括焦虑、痴呆和抑郁。在这篇综合综述中，我们详细讨论了帕金森病的病理生理学，并介绍了如何通过基于逆转录病毒的系统递送神经营养生长因子，将其用作靶向基因治疗的有效工具。
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