慢病毒介导神经营养因子递送在帕金森病潜在治疗中的理论方法
Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson's Disease.
作者信息
Qudrat Anam, Unni Netra
机构信息
Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Canada.
Faculty of Applied Science and Engineering, University of Toronto, Toronto, Canada.
出版信息
Yale J Biol Med. 2016 Jun 27;89(2):215-25. eCollection 2016 Jun.
Parkinson's disease is a late-onset neurodegenerative disease, characterized by both motor and non-motor symptoms. Motor symptoms include postural instability, rigidity, and tremor, while non-motor symptoms include anxiety, dementia, and depression. In this integrative review, we discuss PD disease pathophysiology in detail and introduce how neurotrophic growth factor delivery via a retroviral-based system can be used as efficacious tools for targeted gene therapy.
帕金森病是一种迟发性神经退行性疾病，其特征为运动症状和非运动症状。运动症状包括姿势不稳、僵硬和震颤，而非运动症状包括焦虑、痴呆和抑郁。在这篇综合综述中，我们详细讨论了帕金森病的病理生理学，并介绍了如何通过基于逆转录病毒的系统递送神经营养生长因子，将其用作靶向基因治疗的有效工具。
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