含与不含局部水杨酸的445纳米和630纳米非处方光疗面罩联合使用与局部过氧化苯甲酰治疗轻至中度寻常痤疮的疗效和耐受性比较
Efficacy and Tolerability of a Combined 445nm and 630nm Over-the-counter Light Therapy Mask with and without Topical Salicylic Acid versus Topical Benzoyl Peroxide for the Treatment of Mild-to-moderate Acne Vulgaris.
作者信息
Nestor Mark S, Swenson Nicole, Macri Angela, Manway Mitchell, Paparone Paige
机构信息
Center for Clinical and Cosmetic Research and Center for Cosmetic Enhancement, Aventura, Florida;; Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
Center for Clinical and Cosmetic Research and Center for Cosmetic Enhancement, Aventura, Florida;
出版信息
J Clin Aesthet Dermatol. 2016 Mar;9(3):25-35. Epub 2016 Mar 1.
OBJECTIVE
To evaluate the efficacy and tolerance of a combined 445nm/630nm light therapy mask for the treatment of mild-to-moderate acne vulgaris with and without topical 1% salicylic acid with retinol versus 2.5% benzoyl peroxide.
DESIGN
A 12-week evaluator-blinded, randomized study. Subjects were randomized to be treated with the 445nm/630nm light therapy mask alone, benzoyl peroxide, or 445nm/630nm light therapy mask with topical 1% salicylic acid with retinol.
PARTICIPANTS
Healthy male and female subjects 12 to 35 years old with Fitzpatrick skin types I to VI and mild-to-moderate facial acne vulgaris.
MEASUREMENTS
The primary endpoint was the change in the number of inflammatory acne lesions after 12 weeks of treatment. Secondary endpoints included the change in noninflammatory acne lesions, change in total acne lesions, change in Investigator Global Acne Assessments, and overall responder rate.
RESULTS
445nm/630nm light therapy mask-treated subjects showed a 24.4-percent improvement in inflammatory acne lesions (p<0.01) versus 17.2 percent (p<0.05) and 22.7 percent (p<0.01) in benzoyl peroxide and 445nm/630nm light therapy mask with topical 1% salicylic acid with retinol, respectively, a 19.5-percent improvement in noninflammatory lesions (p<0.001) versus 6.3 and 4.8 percent for benzoyl peroxide and 445nm/630nm light therapy mask with topical 1% salicylic acid with retinol, respectively. Subjects in the 445nm/630nm light therapy mask group also achieved a 19.0-percent improvement in the Investigator Global Acne Assessment (p<0.001) versus 4.7 percent in benzoyl peroxide and 13.9 percent in 445nm/630nm light therapy mask with topical 1% salicylic acid with retinol (p<0.01). Treatments were well-tolerated overall with trends toward less early irritation in the 445nm/630nm light therapy mask group.
CONCLUSION
445nm/630nm light therapy mask appears to be a safe and effective therapy for mild-to-moderate acne.
目的
评估联合使用445纳米/630纳米光疗面罩，在联合或不联合外用1%水杨酸视黄醇的情况下，与2.5%过氧化苯甲酰相比，治疗轻至中度寻常痤疮的疗效和耐受性。
设计
一项为期12周的评估者盲法随机研究。受试者被随机分为单独接受445纳米/630纳米光疗面罩治疗、过氧化苯甲酰治疗或445纳米/630纳米光疗面罩联合外用1%水杨酸视黄醇治疗。
参与者
年龄在12至35岁之间、Fitzpatrick皮肤分型为I至VI型且患有轻至中度面部寻常痤疮的健康男性和女性受试者。
测量指标
主要终点是治疗12周后炎性痤疮皮损数量的变化。次要终点包括非炎性痤疮皮损的变化、痤疮皮损总数的变化、研究者整体痤疮评估的变化以及总体缓解率。
结果
接受445纳米/630纳米光疗面罩治疗的受试者炎性痤疮皮损改善了24.4%（p<0.01），而过氧化苯甲酰组和联合外用1%水杨酸视黄醇的445纳米/630纳米光疗面罩组分别改善了17.2%（p<0.05）和22.7%（p<0.01）；非炎性皮损分别改善了19.5%（p<0.001），而过氧化苯甲酰组和联合外用1%水杨酸视黄醇的445纳米/630纳米光疗面罩组分别为6.3%和4.8%。445纳米/630纳米光疗面罩组的受试者在研究者整体痤疮评估中也有19.0%的改善（p<0.001），而过氧化苯甲酰组为4.7%，联合外用1%水杨酸视黄醇的445纳米/630纳米光疗面罩组为13.9%（p<0.01）。总体而言，治疗耐受性良好，445纳米/630纳米光疗面罩组早期刺激较少。
结论
对于轻至中度痤疮，445纳米/630纳米光疗面罩似乎是一种安全有效的治疗方法。
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