Department of Dermatology, University of North Carolina School of Medicine, 410 Market Street, #400, Chapel Hill, NC, 27516, USA.
Am J Clin Dermatol. 2015 Aug;16(4):231-242. doi: 10.1007/s40257-015-0127-7.
Acne vulgaris is a very common chronic inflammatory disease of the skin. The clinical features of acne range from non-inflammatory comedones to inflammatory nodules. While often perceived as an adolescent disease, the prevalence remains high into adulthood, and the manifestations can have detrimental psychosocial effects. It is therefore not surprising that many patients are motivated to seek treatment. The existing treatment strategies for acne are complex due to the multifactorial pathogenesis of the disease. Although it is difficult to cure, four categories of medications have proved efficacious in reducing acne lesions: topical agents, systemic antibiotics, systemic retinoids, and hormonal agents. Unfortunately, these medications can cause adverse effects that may limit their use. Typically, these adverse effects are mild and transient and can be remedied by altering the dose or frequency of the offending agent. However, more serious adverse effects can occur that pose a significant health risk to the patient. Understanding how to recognize and manage the adverse effects of common acne therapies is imperative to providing the safest and most appropriate treatment for each patient. This article focuses on the recognition and management of adverse effects associated with current acne medications.
寻常痤疮是一种非常常见的皮肤慢性炎症性疾病。痤疮的临床特征范围从非炎症性粉刺到炎症性结节。虽然通常被认为是一种青少年疾病，但在成年期仍然很常见，其表现可能会对心理健康产生有害影响。因此，许多患者有治疗的动力也就不足为奇了。由于疾病的多因素发病机制，现有的痤疮治疗策略非常复杂。尽管很难治愈，但四类药物已被证明能有效减少痤疮皮损：局部制剂、全身抗生素、全身维 A 酸类药物和激素制剂。不幸的是，这些药物可能会引起不良反应，从而限制其使用。通常，这些不良反应是轻微和短暂的，可以通过改变有问题药物的剂量或频率来解决。但是，更严重的不良反应可能会发生，对患者的健康构成重大风险。了解如何识别和管理常见痤疮治疗方法的不良反应对于为每个患者提供最安全和最合适的治疗至关重要。本文重点介绍与当前痤疮药物相关的不良反应的识别和管理。
