Garcia-Martinez Jorge, Bakker Bjorn, Schukken Klaske M, Simon Judith E, Foijer Floris
Jorge Garcia-Martinez, Bjorn Bakker, Klaske M Schukken, Judith E Simon, Floris Foijer, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV Groningen, The Netherlands.
World J Stem Cells. 2016 Jun 26;8(6):216-22. doi: 10.4252/wjsc.v8.i6.216.
Stem cells hold enormous promise for regenerative medicine as well as for engineering of model systems to study diseases and develop new drugs. The discovery of protocols that allow for generating induced pluripotent stem cells (IPSCs) from somatic cells has brought this promise steps closer to reality. However, as somatic cells might have accumulated various chromosomal abnormalities, including aneuploidies throughout their lives, the resulting IPSCs might no longer carry the perfect blueprint for the tissue to be generated, or worse, become at risk of adopting a malignant fate. In this review, we discuss the contribution of aneuploidy to healthy tissues and how aneuploidy can lead to disease. Furthermore, we review the differences between how somatic cells and stem cells respond to aneuploidy.
干细胞在再生医学以及用于研究疾病和开发新药的模型系统工程方面具有巨大的潜力。能够从体细胞生成诱导多能干细胞（iPSC）的方案的发现，使这一前景更接近现实。然而，由于体细胞在其整个生命过程中可能积累了各种染色体异常，包括非整倍体，由此产生的iPSC可能不再携带生成组织的完美蓝图，或者更糟的是，有发生恶性病变的风险。在这篇综述中，我们讨论了非整倍体对健康组织的影响以及非整倍体如何导致疾病。此外，我们还综述了体细胞和干细胞对非整倍体反应的差异。
