氯胺酮对映体的快速和持续抗抑郁作用。
Ketamine enantiomers in the rapid and sustained antidepressant effects.
作者信息
Muller John, Pentyala Sahana, Dilger James, Pentyala Srinivas
机构信息
Department of Anesthesiology, Stony Brook Medical Center, Stony Brook, NY, USA.
Department of Anesthesiology, Stony Brook Medical Center, Stony Brook, NY 11794, USA.
出版信息
Ther Adv Psychopharmacol. 2016 Jun;6(3):185-92. doi: 10.1177/2045125316631267. Epub 2016 Mar 10.
Abstract
Recent evidence has suggested that the N-methyl-D-aspartate receptor antagonist ketamine shows significant therapeutic effects in major depression and bipolar disorder. This effect is especially important in treatment-resistant depression and depression with suicidal ideation. In this review we explain the mechanism of action, drug efficacy, and the side effects of ketamine; the antidepressive effects of ketamine; the individual effects of ketamine isomers, R(-) ketamine and S(+) ketamine; the effects of the combination of ketamine with electroconvulsive therapy; and the possible use of ketamine in treating depression.
摘要
最近的证据表明，N-甲基-D-天冬氨酸受体拮抗剂氯胺酮在重度抑郁症和双相情感障碍中显示出显著的治疗效果。这种效应在难治性抑郁症和伴有自杀意念的抑郁症中尤为重要。在这篇综述中，我们解释了氯胺酮的作用机制、药物疗效和副作用；氯胺酮的抗抑郁作用；氯胺酮异构体R(-)氯胺酮和S(+)氯胺酮的个体效应；氯胺酮与电休克治疗联合使用的效果；以及氯胺酮在治疗抑郁症中的可能用途。
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