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从塞内加尔达喀尔新生儿医院感染中分离出的格伦彭西斯沙门氏菌菌株中首次描述超广谱β-内酰胺酶基因blaCTX-M-109

First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal.

作者信息

Diop Amadou, Sambe-Ba Bissoume, Seck Abdoulaye, Dia Mouhamadou Lamine, Timbiné Lassina Gadi, Niang Aïssatou Ameth, Ndiaye El Hadji Momar, Sonko Mouhamadou Abdoulaye, Wane Abdoul Aziz, Bercion Raymond, Ndiaye Ousmane, Cissé Moussa Fafa, Gassama-Sow Amy

机构信息

Unité de Bactériologie Expérimentale (UBE), Institut Pasteur de Dakar, Dakar, Sénégal.

Laboratoire de Bactériologie-Virologie Centre Hospitalier National d'Enfants Albert Royer de Fann Dakar, Dakar, Sénégal.

出版信息

PLoS One. 2016 Jun 29;11(6):e0157683. doi: 10.1371/journal.pone.0157683. eCollection 2016.

DOI:10.1371/journal.pone.0157683
PMID:27355480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4927072/
Abstract

Nosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections. Here, we report the first description of S. Grumpensis in neonatal infections in Senegal. Seventeen Salmonella strains were isolated from hospitalized infants' stool samples. The following resistance phenotype was described in strains: AMXRTICRCFR FOXRCFXRCTXRCAZRIMPSATMRNARNORRCIPRTMRGMRTERSXTR. All isolates were susceptible to imipenem, 15 out of 17 produced an extended spectrum ß-lactamase (ESBL). blaOXA-1, blaSHV-1, blaTEM-1, blaCTX-M1 genes were detected in strains 8, 13, 5 and 8, respectively. blaCTX-M1 sequencing revealed the presence of blaCTX-M-109. Thirteen of the 17 Salmonella Grumpensis strains were analyzed by PFGE. These 13 isolates belonged to a single pulsotype and were genotypically identical. This is the first report of neonatal S. Grumpensis infections in Senegal, and the first report of blaCTX-M-109 in the genus Salmonella.

摘要

医院感染在非洲医院非常常见，尤其是在新生儿病房。这些感染最常由大肠杆菌、克雷伯菌属和葡萄球菌属等细菌引起。沙门氏菌菌株很少参与医院感染。在此，我们报告了塞内加尔新生儿感染中格鲁姆彭西斯沙门氏菌的首次描述。从住院婴儿的粪便样本中分离出17株沙门氏菌菌株。在菌株中描述了以下耐药表型：AMXRTICRCFR FOXRCFXRCTXRCAZRIMPSATMRNARNORRCIPRTMRGMRTERSXTR。所有分离株对亚胺培南敏感，17株中有15株产生超广谱β-内酰胺酶（ESBL）。分别在菌株8、13、5和8中检测到blaOXA - 1、blaSHV - 1、blaTEM - 1、blaCTX - M1基因。blaCTX - M1测序显示存在blaCTX - M - 109。对17株格鲁姆彭西斯沙门氏菌中的13株进行了脉冲场凝胶电泳（PFGE）分析。这13株分离株属于单一脉冲型，基因型相同。这是塞内加尔新生儿格鲁姆彭西斯沙门氏菌感染的首次报告，也是沙门氏菌属中blaCTX - M - 109的首次报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/4927072/8fb3d9688615/pone.0157683.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/4927072/8fb3d9688615/pone.0157683.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd49/4927072/8fb3d9688615/pone.0157683.g001.jpg

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