Nonoyama Hiroshi, Tanigawa Tohru, Shibata Rei, Nakao Yoshio, Horibe Yuichiro, Katahira Nobuyuki, Nishimura Kunihiro, Murotani Kenta, Murohara Toyoaki, Ueda Hiromi
a Department of Otolaryngology , Aichi Medical University , Aichi , Japan.
b Department of Cardiology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
Acta Otolaryngol. 2016 Nov;136(11):1137-1140. doi: 10.1080/00016489.2016.1195919. Epub 2016 Jun 29.
Red cell distribution width (RDW) can predict outcome in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Further studies are required to clarify the potential pathophysiological explanations for these findings.
RDW is one of the parameters reported in a complete blood count, and is elevated in direct proportion to variation in red cell size (anisocytosis). High RDW values are strongly associated with poor clinical outcomes in various diseases, including inflammatory and thrombotic diseases. To identify a prognostic biomarker that better predicts outcomes after ISSNHL, the association between RDW values at hospitalization and prognosis in patients with ISSNHL was assessed.
This study measured RDW and performed hearing assessments in 89 consecutive patients with ISSNHL. Patients were then divided into two groups ('recovered' and 'unrecovered'), according to their response to the treatment, and further analysis undertaken.
Mean RDW was significantly higher in the unrecovered group (13.2% ± 1.0% compared with 12.7% ± 0.7% in the recovered group, p = 0.031). After adjusting for potentially confounding factors in a binary logistic regression model, only RDW was associated with recovery from ISSNHL (odds ratio = 2.33, 95% confidence interval = 1.20-4.51, p = 0.012).
红细胞分布宽度（RDW）可预测特发性突发性感音神经性听力损失（ISSNHL）患者的预后。需要进一步研究以阐明这些发现潜在的病理生理学解释。
RDW是全血细胞计数报告的参数之一，与红细胞大小的变化（红细胞大小不均）成正比升高。高RDW值与包括炎症性和血栓性疾病在内的各种疾病的不良临床结局密切相关。为了确定一种能更好预测ISSNHL后预后的预后生物标志物，评估了ISSNHL患者住院时RDW值与预后之间的关联。
本研究对89例连续性ISSNHL患者测量了RDW并进行了听力评估。然后根据患者对治疗的反应将其分为两组（“恢复”组和“未恢复”组），并进行进一步分析。
未恢复组的平均RDW显著更高（未恢复组为13.2%±1.0%，恢复组为12.7%±0.7%，p = 0.031）。在二元逻辑回归模型中对潜在混杂因素进行校正后，只有RDW与ISSNHL的恢复相关（比值比 = 2.33，95%置信区间 = 1.20 - 4.51，p = 0.012）。
