Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul 05278, Korea.
Int J Mol Sci. 2021 Dec 28;23(1):307. doi: 10.3390/ijms23010307.
Acute peripheral facial palsy (APFP), including Bell's palsy and Ramsay Hunt syndrome, is a disease that affects daily life through facial motor dysfunction, causing psychological problems. Various tests to evaluate prognosis have been studied; however, there are no validated predictive biomarkers to guide clinical decision making. Therefore, specific biomarkers that respond to treatment are required to understand prognostic outcomes. In this review, we discuss existing literature regarding the role of APFP biomarkers in prognosis and recovery. We searched the PubMed, EMBASE, and Cochrane Library databases for relevant papers. Our screening identified relevant studies and biomarkers correlating with the identification of predictive biomarkers. Only studies published between January 2000 and October 2021 were included. Our search identified 5835 abstracts, of which 35 were selected. All biomarker samples were obtained from blood and were used in the evaluation of disease severity and prognosis associated with recovery. These biomarkers have been effective prognostic or predictive factors under various conditions. Finally, we classified them into five categories. There is no consensus in the literature on the correlation between outcomes and prognostic factors for APFP. Furthermore, the correlation between hematologic laboratory values and APFP prognosis remains unclear. However, it is important to identify new methods for improving the accuracy of facial paralysis prognosis prediction. Therefore, we systematically evaluated prognostic and potentially predictive APFP biomarkers. Unfortunately, a predictive biomarker validating APFP prognosis remains unknown. More prospective studies are required to reveal and identify promising biomarkers providing accurate prognosis.
急性周围性面瘫（APFP），包括贝尔麻痹和 Ramsay Hunt 综合征，是一种通过面部运动功能障碍影响日常生活并导致心理问题的疾病。已经研究了各种评估预后的测试；然而，没有经过验证的预测生物标志物来指导临床决策。因此，需要特定的对治疗有反应的生物标志物来了解预后结果。在这篇综述中，我们讨论了现有的关于 APFP 生物标志物在预后和恢复中的作用的文献。我们在 PubMed、EMBASE 和 Cochrane Library 数据库中搜索了相关论文。我们的筛选确定了相关的研究和与预测生物标志物识别相关的生物标志物。仅纳入了 2000 年 1 月至 2021 年 10 月期间发表的研究。我们的搜索共确定了 5835 篇摘要，其中 35 篇被选中。所有生物标志物样本均来自血液，并用于评估与恢复相关的疾病严重程度和预后。这些生物标志物在各种情况下都是有效的预后或预测因素。最后，我们将它们分为五类。文献中关于 APFP 结局与预后因素之间的相关性尚无共识。此外，血液实验室值与 APFP 预后之间的相关性仍不清楚。然而，识别改善面瘫预后预测准确性的新方法非常重要。因此，我们系统地评估了 APFP 的预后和潜在预测生物标志物。不幸的是，尚无验证 APFP 预后的预测性生物标志物。需要更多的前瞻性研究来揭示和确定提供准确预后的有前途的生物标志物。
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