Chen Yamei, Liu Delong
1 Department of Hematology, Xiamen Zhongshan Hospital, Xiamen 361001, China ; 2 Henan Tumor Hospital, Zhengzhou University, Zhengzhou 450003, China.
Stem Cell Investig. 2014 Apr 2;1:8. doi: 10.3978/j.issn.2306-9759.2014.03.05. eCollection 2014.
Hematopoietic stem cells (HSCs) can take one of the three different pathways: quiescence, self-renewal and differentiation. Mechanisms that control the tight balance to maintain lifelong hematopoietic homeostasis have been a major interest of research. Platelet factor-4 (PF4), a weak chemokine, is synthesized exclusively by megakaryocytes and sequestered in platelets. This meeting report highlights a novel study presented at 2013 ASH annual meeting. This study found that megakaryocyte, a progeny of HSC, was involved in maintaining quiescence of HSCs via PF4 in a feedback loop.
造血干细胞（HSCs）可以采取三种不同途径之一：静止、自我更新和分化。控制维持终身造血稳态的精确平衡的机制一直是研究的主要兴趣所在。血小板因子4（PF4）是一种弱趋化因子，仅由巨核细胞合成并储存在血小板中。本会议报告重点介绍了在2013年美国血液学会年会上发表的一项新研究。该研究发现，作为造血干细胞后代的巨核细胞，通过PF4以反馈回路参与维持造血干细胞的静止状态。
