Moss Joe We, Ramji Dipak P
Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Future Med Chem. 2016 Jul;8(11):1317-30. doi: 10.4155/fmc-2016-0072. Epub 2016 Jun 30.
Atherosclerosis, the primary cause of cardiovascular disease (CVD), is a chronic inflammatory disorder in the walls of medium and large arteries. CVD is currently responsible for about one in three global deaths and this is expected to rise in the future due to an increase in the prevalence of obesity and diabetes. Current therapies for atherosclerosis mainly modulate lipid homeostasis and while successful at reducing the risk of a CVD-related death, they are associated with considerable residual risk and various side effects. There is, therefore, a need for alternative therapies aimed at regulating inflammation in order to reduce atherogenesis. This review will highlight the key role cytokines play during disease progression as well as potential therapeutic strategies to target them.
动脉粥样硬化是心血管疾病（CVD）的主要病因，是中大型动脉血管壁的一种慢性炎症性疾病。目前，心血管疾病导致的死亡人数约占全球总死亡人数的三分之一，而且由于肥胖症和糖尿病患病率的上升，预计这一比例在未来还会增加。目前针对动脉粥样硬化的治疗主要是调节脂质稳态，虽然在降低心血管疾病相关死亡风险方面取得了成功，但它们仍存在相当大的残余风险和各种副作用。因此，需要有旨在调节炎症以减少动脉粥样硬化形成的替代疗法。本综述将重点介绍细胞因子在疾病进展过程中所起的关键作用以及针对它们的潜在治疗策略。
