Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, UK.
Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, UK.
Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1562-1572. doi: 10.1016/j.bbadis.2018.02.006. Epub 2018 Feb 14.
Atherosclerosis, a chronic inflammatory disorder of medium and large arteries and an underlying cause of cardiovascular disease (CVD), is responsible for a third of all global deaths. Current treatments for CVD, such as optimized statin therapy, are associated with considerable residual risk and several side effects in some patients. The outcome of research on the identification of alternative pharmaceutical agents for the treatment of CVD has been relatively disappointing with many promising leads failing at the clinical level. Nutraceuticals, products from food sources with health benefits beyond their nutritional value, represent promising agents in the prevention of CVD or as an add-on therapy with current treatments. This review will highlight the potential of several nutraceuticals, including polyunsaturated fatty acids, flavonoids and other polyphenols, as anti-CVD therapies based on clinical and pre-clinical mechanism-based studies.
动脉粥样硬化是一种中大型动脉的慢性炎症性疾病，也是心血管疾病（CVD）的根本原因，它导致了全球三分之一的死亡。目前针对 CVD 的治疗方法，如优化的他汀类药物治疗，在一些患者中存在相当大的残余风险和一些副作用。在寻找治疗 CVD 的替代药物方面的研究结果相对令人失望，许多有前途的研究在临床层面失败了。营养保健品是具有营养价值以外的健康益处的食物来源产品，它们是预防 CVD 的有前途的药物，或者可以作为当前治疗方法的附加治疗药物。这篇综述将重点介绍几种营养保健品的潜力，包括多不饱和脂肪酸、类黄酮和其他多酚，这些营养保健品基于临床和基于机制的临床前研究，作为抗 CVD 疗法。
