Department of Chemistry, National Tsing Hua University , Hsinchu 30013, Taiwan.
Org Lett. 2016 Jul 15;18(14):3314-7. doi: 10.1021/acs.orglett.6b01281. Epub 2016 Jun 30.
An efficient C-H activation method for the ortho alkynylation of aromatic N-methoxyamides with hypervalent iodine-alkyne reagent using a ruthenium catalyst is described. The reaction proceeds under mild reaction conditions with broad substrate scope. A possible catalytic cycle involving a ruthenium carboxylate assisted C-H bond cleavage is proposed from the preliminary mechanistic evidence.
描述了一种使用钌催化剂的高效 C-H 活化方法，用于芳族 N-甲氧基酰胺与高价碘-炔试剂的邻位炔基化。该反应在温和的反应条件下进行，具有广泛的底物范围。根据初步的机理证据，提出了一个可能的涉及钌羧酸盐辅助的 C-H 键断裂的催化循环。
