Calcium and calmodulin antagonism for inhibition of uterine contractions.
作者信息
Lechner W, Keene F, Marth C, Zech J
机构信息
Department of Obstetrics and Gynecology, University of Innsbruck, Austria.
出版信息
Arch Gynecol Obstet. 1989;244(3):137-9. doi: 10.1007/BF00931290.
PMID:2735773
Abstract
In search for a new tocolytic agent we investigated felodipine, a calmodulin-antagonizing drug. Felodipine reduced the spontaneous activity of 22 uterine strips taken from the uterus in the course of a cesarean section to 52 +/- 12% (mean +/- SEM) after 10 min, to 20 +/- 7% after 20 min and to 12 +/- 4% after 60 min (P less than 0.001).
摘要
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