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分娩时钼、硒和铜的血水平

[Blood levels of molybdenum, selenium and copper at delivery].

作者信息

Bouglé D, Foucault P, Voirin J, Bureau F, Viel J F, Vénézia R, Drosdowsky M, Muller G, Duhamel J F

机构信息

Department de Pédiatrie, C.H.U. de Caen.

出版信息

Arch Fr Pediatr. 1989 Feb;46(2):95-8.

PMID:2735803
Abstract

Molybdenum (Mo), selenium (Se) and copper (Cu) plasma levels were studied at delivery in 38 women (1 twin pregnancy). The influence of parity (P) (2.5 +/- 1.7) gestational age (GA) (38.6 +/- 3.2 weeks), birthweight (BW) (3,120 +/- 695 g) and Apgar score upon these levels were assessed. Mother (M) and cord (C) blood values were 15.0 +/- 7.8 and 15.0 +/- 9.3 nmol/l respectively for Mo, 0.54 +/- 0.12 and 0.47 +/- 014 mumol/l for Se and 27.6 +/- 5.9 and 5.5 +/- 3.3 mumol/l for Cu. C and M values for Se and Cu were statistically different (alpha less than 0.02, alpha less than 0.001). There was a significant correlation between C and M for Mo levels (r = 0.41; p = 1.9%) and Cu levels (r = 0.47; p = 0.35%), between Cu C levels and GA (r = 0.54; p = 0.6%) and between Se, C levels and BW (r = 0.66; p = 1.9%). There was no correlation between the levels of the trace elements studied. This study shows that fetal levels of Mo vary with those of the mothers. On the other hand, the levels of Se in the fetus seem to be protected from variations observed in the mothers. The antagonism between Cu and Mo which had been previously demonstrated in the fetal liver was not found in blood.

摘要

对38名妇女(其中1例为双胎妊娠)分娩时的血浆钼(Mo)、硒(Se)和铜(Cu)水平进行了研究。评估了产次(P)(2.5±1.7)、孕周(GA)(38.6±3.2周)、出生体重(BW)(3120±695克)和阿氏评分对这些水平的影响。母亲(M)和脐带血(C)中钼的水平分别为15.0±7.8和15.0±9.3纳摩尔/升,硒的水平分别为0.54±0.12和0.47±0.14微摩尔/升,铜的水平分别为27.6±5.9和5.5±3.3微摩尔/升。脐带血和母亲血中硒和铜的值在统计学上有差异(α<0.02,α<0.001)。脐带血和母亲血中钼水平(r = 0.41;p = 1.9%)和铜水平(r = 0.47;p = 0.35%)之间、脐带血铜水平和孕周之间(r = 0.54;p = 0.6%)以及脐带血硒水平和出生体重之间(r = 0.66;p = 1.9%)存在显著相关性。所研究的微量元素水平之间没有相关性。本研究表明,胎儿体内钼的水平随母亲体内的水平而变化。另一方面,胎儿体内硒水平似乎不受母亲体内硒水平变化的影响。先前在胎儿肝脏中证明的铜和钼之间的拮抗作用在血液中未发现。

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