Srivastava S, Mehrotra P K, Srivastava S P, Siddiqui M K J
University of Faizabad, India.
Biol Trace Elem Res. 2002 May;86(2):97-105. doi: 10.1385/BTER:86:2:097.
Maternal and cord blood were collected from 54 Indian women at parturition and analyzed for Zn, Cu, and Fe by flame atomic absorption spectrophotometry to determine the relationship between levels of these elements in mother's and infant's blood and maternal age, birth weight, and gestational age of the baby. The blood Zn level of mothers in the age group 24-28 yr was significantly higher than those of mothers in the age group of 18-23 yr (p<0.05). Similarly, mothers in the 24 to 28-yr group also had higher blood Fe level than mothers in the group 29-38 yr (p<0.05). The levels of Zn, Cu, and Fe were higher in the maternal blood and lower, but not significantly, in the cord blood of low-birth-weight babies than in those of normal-birth-weight babies. However, differences in the levels of Zn, Cu, and Fe between maternal and cord blood of the two birth-weight groups was statistically significant. There were no significant differences in the levels of the three elements in maternal or cord blood by the gestational age of the baby. A weak but significant correlation was found between the birth weight of the baby and the Fe level in the cord blood (r=0.26; p<0.05). Also, weak significant correlations were observed between gestational age of the baby and Fe (r=0.23; p<0.05) and Cu (r=0.31; p<0.05) levels in the cord blood. Although, there are many confounders of low birth weight and preterm deliveries, a diminished placental transfer of these essential elements could be one of the several etiological factors for low birth weight of newborns.
在分娩时从54名印度女性身上采集了母血和脐带血，通过火焰原子吸收分光光度法分析其中的锌、铜和铁，以确定母亲和婴儿血液中这些元素的水平与母亲年龄、出生体重和婴儿孕周之间的关系。24 - 28岁年龄组母亲的血锌水平显著高于18 - 23岁年龄组的母亲（p<0.05）。同样，24至28岁组的母亲血铁水平也高于29 - 38岁组的母亲（p<0.05）。低出生体重儿脐带血中的锌、铜和铁水平低于母血，但差异不显著，不过两个出生体重组母血和脐带血中锌、铜和铁水平的差异具有统计学意义。按婴儿孕周划分，母血或脐带血中这三种元素的水平没有显著差异。婴儿出生体重与脐带血中铁水平之间存在微弱但显著的相关性（r = 0.26；p<0.05）。此外，还观察到婴儿孕周与脐带血中铁（r = 0.23；p<0.05）和铜（r = 0.31；p<0.05）水平之间存在微弱的显著相关性。尽管低出生体重和早产有许多混杂因素，但这些必需元素的胎盘转运减少可能是新生儿低出生体重的多种病因之一。
