Kos Mehmet, Hocazade Cemil, Kos F Tugba, Uncu Dogan, Karakas Esra, Dogan Mutlu, Uncu Hikmet G, Ozdemir Nuriye, Zengin Nurullah
Department of Internal Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey.
Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Contemp Oncol (Pozn). 2016;20(2):153-7. doi: 10.5114/wo.2016.60072. Epub 2016 Jun 14.
Data are available indicating that red blood cell distribution width (RDW) is higher in cancer patients compared to healthy individuals or benign events. In our study, we aimed to investigate the influence of different RDW levels on survival in lung cancer patients.
Clinical and laboratory data from 146 patients with lung cancer and 40 healthy subjects were retrospectively studied. RDW was recorded before the application of any treatment. Patients were categorised according to four different RDW cut-off values (median RDW, RDW determined by ROC curve analysis, the upper limit at the automatic blood count device, and RDW cut of value which used in previous studies). Kaplan-Meier survival analysis was used to examine the effect of RDW on survival for each cut-off level.
The median age of patients was 56.5 years (range: 26-83 years). The difference in median RDW between patients and the control group was statistically significant (14.0 and 13.8, respectively, p = 0.04). There was no difference with regard to overall survival when patients with RDW ≥ 14.0 were compared to those with RDW < 14.0 (p = 0.70); however, overall survival was 3.0 months shorter in low values of its own group in each of the following cut-off values: ≥ 14.2 (p = 0.34), ≥ 14.5 (p = 0.25), ≥ 15 (p = 0.59), although no results were statistically significant.
We consider that the difference between low and high RDW values according to certain cut-off values may reflect the statistics of larger studies although there is a statistically negative correlation between RDW level and survival.
现有数据表明，与健康个体或良性疾病患者相比，癌症患者的红细胞分布宽度（RDW）更高。在我们的研究中，我们旨在调查不同RDW水平对肺癌患者生存的影响。
回顾性研究了146例肺癌患者和40例健康受试者的临床和实验室数据。在应用任何治疗之前记录RDW。根据四个不同的RDW临界值（中位数RDW、通过ROC曲线分析确定的RDW、自动血细胞计数设备的上限以及先前研究中使用的RDW临界值）对患者进行分类。采用Kaplan-Meier生存分析来检验每个临界值水平下RDW对生存的影响。
患者的中位年龄为56.5岁（范围：26 - 83岁）。患者与对照组之间的中位数RDW差异具有统计学意义（分别为14.0和13.8，p = 0.04）。将RDW≥14.0的患者与RDW < 14.0的患者进行比较时，总生存无差异（p = 0.70）；然而，在以下每个临界值水平下，低RDW值组自身的总生存均缩短3.0个月：≥14.2（p = 0.34）、≥14.5（p = 0.25）、≥15（p = 0.59），尽管结果均无统计学意义。
我们认为，尽管RDW水平与生存之间存在统计学上的负相关，但根据某些临界值划分的低RDW值和高RDW值之间的差异可能反映了更大规模研究的统计情况。
