Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney NSW 2010, Australia.
In Vivo. 2012 Jul-Aug;26(4):627-46.
The association between chronic inflammation and cancer has been noted for at least a century but the exact molecular mechanisms of cancer initiation and promotion by such inflammation are still poorly understood. The gastrointestinal tract is a unique organ where maintaining a balance between the colonic epithelial cells, the immune system and a fine-tuned response to the resident microflora is crucial for preserving the gut homeostasis. A breakdown of the tight interdependent regulation of the epithelium-immunity-microbiota triangle leads to inflammatory bowel disorders and may promote cancer. This review focuses on inflammation-associated colorectal cancer in mouse models of the disease and highlights emerging research trends.
慢性炎症与癌症之间的关联至少已有一个世纪之久，但这种炎症引发和促进癌症的确切分子机制仍知之甚少。胃肠道是一个独特的器官，其中结肠上皮细胞、免疫系统和对常驻微生物区系的精细反应之间的平衡对于维持肠道内稳态至关重要。上皮细胞-免疫-微生物群三角关系的紧密相互依存调节的崩溃会导致炎症性肠病，并可能促进癌症。这篇综述重点关注疾病的小鼠模型中的炎症相关结直肠癌，并强调了新兴的研究趋势。
