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致命性出血性肺炎:勿忘嗜麦芽窄食单胞菌。

Fatal hemorrhagic pneumonia: Don't forget Stenotrophomonas maltophilia.

作者信息

Gutierrez Cristina, Pravinkumar Egbert, Balachandran Dave, Schneider Virginia

机构信息

Department of Critical Care, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Respir Med Case Rep. 2016 Jun 14;19:12-4. doi: 10.1016/j.rmcr.2016.06.003. eCollection 2016.

DOI:10.1016/j.rmcr.2016.06.003
PMID:27358764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4915958/
Abstract

We present a case of fatal hemorrhagic pneumonia secondary to Stenotrophomonas maltophilia in a patient with acute myeloid leukemia. S. maltophilia is commonly a non-virulent pathogen. However, in the immunocompromised, it is generally associated with bacteremia after central venous catheter placement or pneumonia. Hemorrhagic pneumonia is a rare presentation of this bacteria, with only 31 cases reported in the literature, and has 100% mortality within 72 hours. Rapid recognition and early suspicion should be key in the treatment of these patients.

摘要

我们报告一例急性髓系白血病患者继发嗜麦芽窄食单胞菌所致的致命性出血性肺炎。嗜麦芽窄食单胞菌通常是一种无毒性的病原体。然而,在免疫功能低下的患者中,它通常与中心静脉导管置入后发生的菌血症或肺炎有关。出血性肺炎是这种细菌罕见的表现形式,文献中仅报道了31例,且在72小时内死亡率达100%。快速识别和早期怀疑对于这些患者的治疗至关重要。

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本文引用的文献

1
Haemorrhagic pneumonia caused by Stenotrophomonas maltophilia in two newborns.两例新生儿嗜麦芽窄食单胞菌所致出血性肺炎
J Infect Dev Ctries. 2015 May 18;9(5):533-5. doi: 10.3855/jidc.5463.
2
Infections Caused by Stenotrophomonas maltophilia in Recipients of Hematopoietic Stem Cell Transplantation.造血干细胞移植受者感染嗜麦芽窄食单胞菌。
Front Oncol. 2014 Aug 25;4:232. doi: 10.3389/fonc.2014.00232. eCollection 2014.
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Life-threatening hemorrhagic pneumonia caused by Stenotrophomonas maltophilia in the treatment of hematologic diseases.
连续血小板水平指数可改善对呼吸道感染合并血小板减少症患者肺出血的预测。
Front Med (Lausanne). 2022 Sep 2;9:940159. doi: 10.3389/fmed.2022.940159. eCollection 2022.
4
Prognosis of hospital-acquired pneumonia/ventilator-associated pneumonia with Stenotrophomonas maltophilia versus Klebsiella pneumoniae in intensive care unit: A retrospective cohort study.耐甲氧西林寡养单胞菌与肺炎克雷伯菌所致 ICU 获得性肺炎/呼吸机相关性肺炎的预后比较:一项回顾性队列研究。
Clin Respir J. 2022 Oct;16(10):669-676. doi: 10.1111/crj.13537. Epub 2022 Aug 31.
5
Fatal hemorrhagic pneumonia in patients with hematologic diseases and Stenotrophomonas maltophilia bacteremia: a retrospective study.血液系统疾病合并嗜麦芽窄食单胞菌菌血症患者的致死性出血性肺炎:一项回顾性研究。
BMC Infect Dis. 2021 Jul 31;21(1):723. doi: 10.1186/s12879-021-06420-0.
6
Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia - case report.成功治疗急性淋巴细胞白血病患者暴发性嗜麦芽窄食单胞菌呼吸道感染引起的肺出血和急性呼吸窘迫综合征——病例报告。
BMC Infect Dis. 2020 Sep 10;20(1):658. doi: 10.1186/s12879-020-05378-9.
7
Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌引起的快速进展性致死性出血性肺炎的临床特征
Intern Med. 2020;59(2):193-198. doi: 10.2169/internalmedicine.3358-19. Epub 2020 Jan 15.
8
Pathogenic significance of hemorrhagic pneumonia in hematologic malignancy patients with Stenotrophomonas maltophilia bacteremia: clinical and microbiological analysis.血液恶性肿瘤合并嗜麦芽窄食单胞菌菌血症患者出血性肺炎的发病意义:临床与微生物学分析。
Eur J Clin Microbiol Infect Dis. 2019 Feb;38(2):285-295. doi: 10.1007/s10096-018-3425-1. Epub 2018 Nov 12.
嗜麦芽窄食单胞菌导致的危及生命的出血性肺炎在血液病治疗中的作用。
Ann Hematol. 2014 Jun;93(6):901-11. doi: 10.1007/s00277-014-2028-x. Epub 2014 Feb 18.
4
Rapidly progressive fatal hemorrhagic pneumonia caused by Stenotrophomonas maltophilia in hematologic malignancy.嗜麦芽窄食单胞菌引起的血液系统恶性肿瘤患者快速进展性致死性出血性肺炎
Transpl Infect Dis. 2012 Aug;14(4):355-63. doi: 10.1111/j.1399-3062.2011.00710.x. Epub 2012 Jan 30.
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Stenotrophomonas maltophilia: an emerging global opportunistic pathogen.嗜麦芽寡养单胞菌:一种新兴的全球机会性病原体。
Clin Microbiol Rev. 2012 Jan;25(1):2-41. doi: 10.1128/CMR.00019-11.
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Stenotrophomonas maltophilia: changing spectrum of a serious bacterial pathogen in patients with cancer.嗜麦芽窄食单胞菌:癌症患者中一种严重细菌病原体的变化谱。
Clin Infect Dis. 2007 Dec 15;45(12):1602-9. doi: 10.1086/522998.
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Stenotrophomonas maltophilia pneumonia in cancer patients without traditional risk factors for infection, 1997-2004.1997 - 2004年无传统感染危险因素的癌症患者嗜麦芽窄食单胞菌肺炎
Eur J Clin Microbiol Infect Dis. 2007 Jan;26(1):13-20. doi: 10.1007/s10096-006-0243-7.
8
The major extracellular protease of the nosocomial pathogen Stenotrophomonas maltophilia: characterization of the protein and molecular cloning of the gene.医院病原体嗜麦芽窄食单胞菌的主要细胞外蛋白酶:蛋白质特性及基因的分子克隆
J Biol Chem. 2002 Mar 29;277(13):11042-9. doi: 10.1074/jbc.M109525200. Epub 2002 Jan 16.
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In vitro activity of moxifloxacin against Stenotrophomonas maltophilia blood isolates from patients with hematologic malignancies.莫西沙星对血液系统恶性肿瘤患者嗜麦芽窄食单胞菌血液分离株的体外活性
Clin Microbiol Infect. 2001 Jan;7(1):37-9.