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血液系统恶性肿瘤患者感染导致的出血性肺炎:系统评价和荟萃分析。

Hemorrhagic Pneumonia Caused by in Patients with Hematologic Malignancies-A Systematic Review and Meta-Analysis.

机构信息

Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Min-Sheng Road, Dalin Town, Taiwan.

Department of Nursing, Dalin Tzu Chi Hospital, No. 2, Min-Sheng Road, Dalin Town, Taiwan.

出版信息

Medicina (Kaunas). 2024 Jan 15;60(1):162. doi: 10.3390/medicina60010162.

Abstract

There is a need for information regarding the clinical picture of hemorrhagic pneumonia caused by in patients with hematologic malignancies. In this study, we aimed to investigate the risk factors associated with hemorrhagic pneumonia caused by : A review of the clinical picture of hemorrhagic pneumonia based on reported cases in the literature was performed. In addition, patients with hematologic malignancies who had a infection were included in the meta-analysis to evaluate risk factors for hemorrhagic pneumonia. : A total of 91 patients had hemorrhagic pneumonia. Acute myeloid leukemia was present in 57 patients (62.6%). Those with bacteremia accounted for 94%, while those with neutropenia accounted for 95% and those with thrombocytopenia accounted for 86.7%. Hemorrhagic pneumonia was a risk factor for mortality of infection in patients with hematologic malignancies. Neutropenia and thrombocytopenia were identified as risk factors for hemorrhagic pneumonia. : bacteremia with hemorrhagic pneumonia in patients with hematologic malignancies is a situation with rapid development and high mortality. Neutropenia and thrombocytopenia were risk factors for hemorrhagic pneumonia in patients with hematologic malignancies and with bacteremia; thus, these patients should be managed with caution.

摘要

目前需要了解血液恶性肿瘤患者感染引起的出血性肺炎的临床特征。本研究旨在探讨血液恶性肿瘤患者感染引起出血性肺炎的相关危险因素。我们通过文献报道的病例回顾了出血性肺炎的临床特征,并对感染的血液恶性肿瘤患者进行了荟萃分析,以评估出血性肺炎的危险因素。共纳入 91 例发生出血性肺炎的患者,其中急性髓系白血病 57 例(62.6%)。94%的患者发生菌血症,95%的患者中性粒细胞减少,86.7%的患者血小板减少。出血性肺炎是血液恶性肿瘤患者感染相关死亡的危险因素。中性粒细胞减少和血小板减少是血液恶性肿瘤合并菌血症患者发生出血性肺炎的危险因素。血液恶性肿瘤患者合并菌血症合并出血性肺炎病情进展迅速,死亡率高。中性粒细胞减少和血小板减少是血液恶性肿瘤合并菌血症患者发生出血性肺炎的危险因素,对此类患者应谨慎处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e6c/10819368/98a1246b26f1/medicina-60-00162-g001.jpg

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