微小RNA作为白血病的生物标志物
MicroRNAs as biomarkers in leukemia.
作者信息
Wang Xinxin, Zhu Baohua, Huang Zunnan, Chen Liyong, He Zhiwei, Zhang Hua
机构信息
China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
出版信息
Stem Cell Investig. 2014 May 27;1:11. doi: 10.3978/j.issn.2306-9759.2014.04.01. eCollection 2014.
Current diagnostic and prognostic markers still exhibit biological limitation and seeking novel molecular biomarkers is crucial for early clinical diagnosis and in the development of novel strategies for leukemia therapy. Emerging evidence showed that dysregulated microRNAs (miRNAs) play important roles in cancer including leukemia. In this review, we summarized recent progress on the role of miRNAs in leukemia, mainly focusing on recent findings that suggest the potential of miRNAs as biomarkers for diagnosis and prognosis. Notably, the circulating miRNAs were also discussed for the fact that they can be detected in body fluids, and thus represent a novel source of promising biomarkers that may be applied to clinical settings.
当前的诊断和预后标志物仍存在生物学局限性，寻找新型分子生物标志物对于白血病的早期临床诊断以及新治疗策略的开发至关重要。新出现的证据表明，失调的微小RNA（miRNA）在包括白血病在内的癌症中发挥着重要作用。在本综述中，我们总结了miRNA在白血病中作用的最新进展，主要关注近期表明miRNA作为诊断和预后生物标志物潜力的研究发现。值得注意的是，还讨论了循环miRNA，因为它们可以在体液中检测到，因此代表了一种有望应用于临床的新型生物标志物来源。
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