China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
J Hematol Oncol. 2013 May 31;6:37. doi: 10.1186/1756-8722-6-37.
Emerging evidence showed that long non-coding RNAs (lncRNAs) play important roles in a wide range of biological processes and dysregulated lncRNAs are involved in many complex human diseases, including cancer. Although a few lncRNAs' functions in cancer have been characterized, the detailed regulatory mechanisms of majority of lncRNAs in cancer initiation and progression remain largely unknown. In this review, we summarized recent progress on the mechanisms and functions of lncRNAs in cancer, especially focusing on the oncogenic and tumor suppressive roles of the newly identified lncRNAs, and the pathways these novel molecules might be involved in. Their potentials as biomarkers for diagnosis and prognosis in cancer are also discussed in this paper.
新兴证据表明，长非编码 RNA（lncRNA）在广泛的生物学过程中发挥着重要作用，失调的 lncRNA 参与了许多复杂的人类疾病，包括癌症。尽管已经确定了少数 lncRNA 在癌症中的功能，但大多数 lncRNA 在癌症发生和发展中的详细调控机制在很大程度上仍然未知。在这篇综述中，我们总结了 lncRNA 在癌症中的作用机制和功能的最新进展，特别是重点介绍了新鉴定的 lncRNA 的致癌和肿瘤抑制作用，以及这些新分子可能涉及的途径。本文还讨论了它们作为癌症诊断和预后标志物的潜力。
