由G-四链体DNA金属酶催化的对映选择性硫氧化反应。
Enantioselective sulfoxidation reaction catalyzed by a G-quadruplex DNA metalloenzyme.
作者信息
Cheng Mingpan, Li Yinghao, Zhou Jun, Jia Guoqing, Lu Sheng-Mei, Yang Yan, Li Can
机构信息
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
出版信息
Chem Commun (Camb). 2016 Jul 26;52(62):9644-7. doi: 10.1039/c6cc03016e.
PMID:27359255
Abstract
Enantioselective sulfoxidation reaction is achieved for the first time by a DNA metalloenzyme assembled with the human telomeric G-quadruplex DNA and Cu(ii)-4,4'-bimethyl-2,2'-bipyridine complex, and the mixed G-quadruplex architectures are responsible for the catalytic enantioselectivity and activity.
摘要
通过将人端粒G-四链体DNA与Cu（II）-4,4'-二甲基-2,2'-联吡啶配合物组装而成的DNA金属酶首次实现了对映选择性硫氧化反应，并且混合的G-四链体结构负责催化对映选择性和活性。
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