Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50 370 Wrocław, Poland.
Faculty of Chemistry, University of Wrocław 14 F. Joliot-Curie St., 50 383 Wrocław, Poland.
Chem Rev. 2020 May 27;120(10):4578-4611. doi: 10.1021/acs.chemrev.0c00002. Epub 2020 Apr 29.
Chiral sulfinyl compounds, sulfoxides, sulfoximines, sulfinamides, and other derivatives, play an important role in asymmetric synthesis as versatile auxiliaries, ligands, and catalysts. They are also recognized as pharmacophores found in already marketed and well-sold drugs (e.g., esomeprazole) and used in drug design. This review is devoted to the modern methods of preparation of sulfinyl derivatives in enantiopure or enantiomerically enriched form. Selected new approaches leading to racemic products for which the asymmetric variant can be developed in the future are mentioned as well.
手性亚砜化合物、亚砜、亚磺酰胺、磺酰胺和其他衍生物在不对称合成中作为多功能助剂、配体和催化剂发挥着重要作用。它们也被认为是已上市且畅销药物（例如埃索美拉唑）中的药效团，并用于药物设计。本综述致力于介绍制备手性亚砜衍生物的现代方法，包括对映纯或对映体富集形式。此外，还提到了一些新的方法，这些方法可以得到外消旋产物，未来可以开发其不对称变体。
