Hovda D A, Sutton R L, Feeney D M
University of New Mexico.
Behav Neurosci. 1989 Jun;103(3):574-84. doi: 10.1037//0735-7044.103.3.574.
After bilateral visual cortex ablation, cats exhibit a loss of depth perception as measured on a visual cliff, which recovers following administration of d-amphetamine. In this Study, 3 amphetamine-treated cats with visual cortex ablations showed a rapid and enduring recovery, with 2 of these animals obtaining levels of performance seen only with binocular vision, suggesting a restoration of binocular depth perception. Cats with asymmetrical lesions showed only a transient improvement during amphetamine treatment, and some animals not displaying autonomic signs of amphetamine intoxication did not improve. Saline-treated cats showed no signs of improvement, and the effect of amphetamine was blocked by the catecholaminergic antagonist haloperidol. These results indicate that amphetamine can induce an enduring recovery from a behavioral deficit after brain injury, which if left untreated would not spontaneously recover.
双侧视觉皮层切除术后，猫在视觉悬崖测试中表现出深度感知丧失，而给予d-苯丙胺后这种情况会恢复。在本研究中，3只接受苯丙胺治疗的视觉皮层切除猫表现出快速且持久的恢复，其中2只动物达到了仅在双眼视觉时才有的表现水平，这表明双眼深度感知得到了恢复。有不对称损伤的猫在苯丙胺治疗期间仅表现出短暂改善，并且一些未表现出苯丙胺中毒自主体征的动物没有改善。用生理盐水治疗的猫没有改善迹象，并且苯丙胺的作用被儿茶酚胺能拮抗剂氟哌啶醇阻断。这些结果表明，苯丙胺可以诱导脑损伤后行为缺陷的持久恢复，若不治疗则不会自发恢复。
