Feeney D M, Hovda D A
Psychopharmacology (Berl). 1983;79(1):67-71. doi: 10.1007/BF00433018.
Unilateral motor cortex injury in the cat results in a prolonged loss of tactile placing in the forelimb contralateral to the injury. Amphetamine (5 mg/kg) temporarily reverses this tactile placing deficit as early as 4 days following the injury. Racemic amphetamine was found to produce a significantly more prolonged restoration of placing than the d isomer, which was significantly more effective than the l isomer. Haloperidol (0.4 mg/kg) blocked the amphetamine-induced recovery of placing responses and also blocked placing in nondrugged cats showing partial spontaneous recovery. This dosage of haloperidol had no effect on tactile placing in normal cats. Apomorphine at moderate dosages (0.25 and 0.5 mg/kg) produced a weak restoration of tactile placing in motor cortex-injured animals. These pharmacological data suggest that the loss of tactile placing after motor cortex injury is due to a depression of catecholaminergic function, which is temporarily reversible by catecholaminergic stimulation.
猫的单侧运动皮层损伤会导致损伤对侧前肢的触觉放置能力长期丧失。早在损伤后4天，苯丙胺（5毫克/千克）就能暂时逆转这种触觉放置缺陷。研究发现，消旋苯丙胺比右旋异构体能更显著地延长放置能力的恢复时间，而右旋异构体比左旋异构体的效果显著更好。氟哌啶醇（0.4毫克/千克）阻断了苯丙胺诱导的放置反应恢复，也阻断了未用药但有部分自发恢复的猫的放置能力。这个剂量的氟哌啶醇对正常猫的触觉放置没有影响。中等剂量（0.25和0.5毫克/千克）的阿扑吗啡能使运动皮层损伤动物的触觉放置能力得到微弱恢复。这些药理学数据表明，运动皮层损伤后触觉放置能力的丧失是由于儿茶酚胺能功能的抑制，而儿茶酚胺能刺激可使其暂时逆转。
