Ritz M C, George F R, Meisch R A
Behavior Genetics Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224.
Alcohol. 1989 May-Jun;6(3):235-9. doi: 10.1016/0741-8329(89)90024-4.
The ethanol-reinforced behavior of ALKO Alcohol Accepting (AA) rats was studied as a function of fixed-ratio (FR) size (1, 2, 4, 8 and 16) across several ethanol concentrations (8, 16 and 32% w/v). A comparison was also made with ethanol-reinforced behavior of Sprague-Dawley (SD) rats. Ethanol, previously shown to serve as a reinforcer in AA and SD rats, maintained responding in these animals under conditions of intermittent reinforcement. SD rats exhibited higher response rates than AA rats to obtain 8% ethanol concentrations as fixed-ratio size was varied in these experiments. These results confirm that, for AA rats, the selection for preference in a two-bottle choice situation did not include the selection for those biological factors which maximize ethanol-reinforced behavior under conditions of intermittent reinforcement. These experiments suggest the existence of distinct, biologically influenced components of ethanol drinking behavior, and have demonstrated several similarities as well as differences between two-bottle choice preference tests and operant studies of ethanol-reinforced behavior.
研究了ALKO酒精接受（AA）大鼠的乙醇强化行为与固定比率（FR）大小（1、2、4、8和16）之间的关系，该关系是在几种乙醇浓度（8%、16%和32% w/v）下进行考察的。还对斯普拉格-道利（SD）大鼠的乙醇强化行为进行了比较。先前已证明乙醇在AA和SD大鼠中可作为强化物，在这些动物中，在间歇性强化条件下，乙醇维持了反应。在这些实验中，随着固定比率大小的变化，SD大鼠在获取8%乙醇浓度时的反应率高于AA大鼠。这些结果证实，对于AA大鼠而言，在双瓶选择情境中对偏好的选择并不包括对那些在间歇性强化条件下能使乙醇强化行为最大化的生物学因素的选择。这些实验表明存在受生物学影响的、不同的乙醇饮用行为成分，并证明了双瓶选择偏好测试与乙醇强化行为的操作性研究之间的一些异同。
