小鼠对静脉注射的Friend细胞的天然抵抗力。III. 体内和体外传代的干扰素敏感（745）和干扰素抗性（3Cl8）细胞克隆之间的比较。
Natural resistance in mice against Friend cells injected intravenously. III. Comparison between in vivo and in vitro passaged interferon-sensitive (745) and interferon-resistant (3Cl8) cell clones.
作者信息
Neri M, Zei T, Bonmassar E, Rossi G B, Fiorucci G, Iorio A N
机构信息
Department of Hygiene, University of Perugia, Italy.
出版信息
Br J Cancer. 1989 Jun;59(6):848-53. doi: 10.1038/bjc.1989.181.
Abstract
In vitro (FLC-Vt) or in vivo (FLC-V) passaged Friend erythroleukaemia cells of DBA/2 origin were tested for susceptibility to natural resistance (NR) in vivo or to NK cell activity in vitro. Scarcely oncogenic FLC-Vt cells were highly susceptible to in vivo NR (measured as rapid organ clearance or growth inhibition in lethally irradiated mice) or to in vitro NK attack. Conversely, highly oncogenic FLC-V cells were weakly susceptible to NR and to NK as well. These data seem to point out that natural immunity, which is up-regulated by endogenous or exogenous interferons, can play a significant role in surveillance against mouse leukaemic cells of retrovirus origin.
摘要
对源自DBA/2的经体外传代（FLC-Vt）或体内传代（FLC-V）的弗氏红白血病细胞进行了体内对天然抵抗力（NR）或体外对NK细胞活性的敏感性测试。几乎无致癌性的FLC-Vt细胞对体内NR（以在致死剂量照射小鼠中的快速器官清除或生长抑制来衡量）或体外NK攻击高度敏感。相反，高致癌性的FLC-V细胞对NR和NK也均不敏感。这些数据似乎表明，由内源性或外源性干扰素上调的天然免疫在监测逆转录病毒起源的小鼠白血病细胞方面可发挥重要作用。
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Expression of metastatic potential of allogenic and xenogeneic neoplasms in young nude mice.年轻裸鼠同种异体和异种肿瘤转移潜能的表达
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Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural killer cell-mediated cytotoxicity.年轻裸鼠体内肿瘤细胞转移潜能的表达与自然杀伤细胞介导的低细胞毒性水平相关。
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Injection of mice with antibody to interferon enhances the growth of transplantable murine tumors.给小鼠注射抗干扰素抗体可增强可移植性小鼠肿瘤的生长。
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Relative contribution of antiproliferative and host immunity-associated activity of mouse interferon in murine tumor therapy.小鼠干扰素的抗增殖活性和宿主免疫相关活性在小鼠肿瘤治疗中的相对贡献。
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Biologic and biochemical differences between in vitro and in vivo passaged Friend erythroleukemia cells. II. Changes in cell surface glycoproteins associated with a highly malignant phenotype.体外和体内传代的弗瑞德红白血病细胞之间的生物学和生物化学差异。II. 与高度恶性表型相关的细胞表面糖蛋白的变化。
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