Giavina-Bianchi Pedro, Aun Marcelo Vivolo, Jares Edgardo José, Kalil Jorge
aClinical Immunology and Allergy Division; University of São Paulo, São Paulo, BrazilbAllergy Unit, CMP S.A., Libra Foundation, Buenos Aires, Argentina.
Curr Opin Allergy Clin Immunol. 2016 Aug;16(4):323-32. doi: 10.1097/ACI.0000000000000292.
The review critically assesses the different phenotypes of angioedemas associated with NSAIDs. Angioedemas exacerbated or induced by NSAIDs have high morbidity and, when they affect the larynx, can lead to death by asphyxiation.
Angioedema can present as a manifestation of a syndrome such as anaphylaxis or it can be a separate entity, which comprises different forms that can be diagnosed based on specific criteria. NSAIDs are the drugs most used worldwide and they are also one of the leading causes of angioedema.
The manuscript addresses the pathophysiology and pharmacogenetics of angioedema, reviews its classification and assesses the diagnosis and management of angioedemas exacerbated and induced by NSAIDs.
本综述对与非甾体抗炎药相关的血管性水肿的不同表型进行了批判性评估。由非甾体抗炎药加重或诱发的血管性水肿发病率很高，当累及喉部时，可导致窒息死亡。
血管性水肿可表现为过敏反应等综合征的一种表现，也可以是一个独立的实体，它包含不同的形式，可根据特定标准进行诊断。非甾体抗炎药是全球使用最广泛的药物之一，也是血管性水肿的主要原因之一。
本文阐述了血管性水肿的病理生理学和药物遗传学，回顾了其分类，并评估了由非甾体抗炎药加重和诱发的血管性水肿的诊断和管理。
