Zhu Xing-Xing, Ding Ya-Hui, Wu Yi, Qian Lin-Yan, Zou Hai, He Qiang
a Department of Nephrology , Zhejiang Provincial People's Hospital , Hangzhou , China.
b Department of Cardiology , Zhejiang Provincial People's Hospital , Hangzhou , China.
Expert Rev Clin Pharmacol. 2016 Oct;9(10):1323-1330. doi: 10.1080/17512433.2016.1208563. Epub 2016 Jul 18.
Silibinin is mixture of flavonolignans extracted from milk thistle and often has been used in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol and hepatitis and gall bladder disorders for its antioxidant and hepatoprotective properties. Areas covered: However, increasing evidence suggest that silibinin is not solely limited in the treatment of these diseases. Further research suggests that silymarin may function diversely and may serve as a novel therapy for cancer therapy, such as lung cancer, prostatic cancer, colon cancer, breast cancer, bladder cancer and hepatocellular carcinoma by regulating cancer cells growth, proliferation, apoptosis, angiogenesis and many other mechanism. Expert commentary: In this review, in order to provide potential new treatment for these cancer, we summarize the recent anti-cancer findings of silibinin in these cancer and clarify the mechanisms of this effect.
水飞蓟宾是从水飞蓟中提取的黄酮木脂素混合物，因其抗氧化和肝脏保护特性，常用于治疗由毒素、药物、酒精和肝炎引起的急慢性肝脏疾病以及胆囊疾病。涵盖领域：然而，越来越多的证据表明，水飞蓟宾并不局限于治疗这些疾病。进一步的研究表明，水飞蓟素可能具有多种功能，并且通过调节癌细胞的生长、增殖、凋亡、血管生成和许多其他机制，可能成为一种新型的癌症治疗方法，如肺癌、前列腺癌、结肠癌、乳腺癌、膀胱癌和肝细胞癌。专家评论：在本综述中，为了为这些癌症提供潜在的新治疗方法，我们总结了水飞蓟宾在这些癌症中的最新抗癌研究结果，并阐明了这种作用的机制。
