脐带血白细胞介素-4 和干扰素-γ受产前母体环境和饮食的影响：一项初步研究。

Effect of the prenatal maternal environments and diets on cord blood interleukin-4 and interferon -gamma: A pilot study.

机构信息

Department of Pediatrics, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul 12841, Korea.

Department of Pediatrics, Dankook University College of Medicine, Cheil General Hospital and Women's Healthcare Center,17,Seoae-ro 1-gil, Jung-gu, Seoul 04619, Korea.

出版信息

Asian Pac J Allergy Immunol. 2017 Mar;35(1):46-53. doi: 10.12932/AP0765.

DOI:10.12932/AP0765

PMID:27362407

Abstract

BACKGROUND AND OBJECTIVE

TThe environment of a pregnant woman can affect not only fetal growth and development, but also diseases in childhood. Neonatal cord blood cytokines are commonly used to evaluate the immune development of neonates. The purpose of this study was to evaluate the effects of the environment and diet during pregnancy on IL-4 and IFN-γ in neonatal cord blood.

METHOD

A total of 111 pregnant women participated in this study from April to November 2010. Allergy history, sensitization assessed by the skin prick test, dietary intake and indoor environment were evaluated. IL-4 and IFN-γ levels were measured in the complete cord blood of neonates using real-time PCR.

RESULTS

There were 54 pregnant women with allergic disease. Both IL-4 and IFN-γ levels in neonatal cord blood were higher in samples from allergic mothers than in non-allergic mothers (p<0.05). The indoor environment and nutrient intake were not different between allergic and non-allergic mothers, except regarding carpet use. When the cytokine levels were divided into quartiles, lower folate and vitamin B6 intake was associated with the highest levels of IL-4 in neonatal cord blood (p<0.05), and higher folate and vitamin B6 intake was associated with highest levels of IFN-γ in neonatal cord blood.

CONCLUSIONS

In this study, a strong association between IL-4 and IFN-γ levels in cord blood and the intake of folate and vitamin B6 was found, which indicates that food intake during pregnancy might have a strong influence on IL-4 and IFN-γ levels in cord blood, to a greater extent than environmental factors.

摘要

背景与目的

孕妇所处的环境不仅会影响胎儿的生长发育，还会影响儿童时期的疾病。新生儿脐血细胞因子常用于评估新生儿的免疫发育。本研究旨在评估孕期环境和饮食对新生儿脐血中 IL-4 和 IFN-γ 的影响。

方法

2010 年 4 月至 11 月，共有 111 名孕妇参与了本研究。评估过敏史、皮肤点刺试验评估的致敏情况、饮食摄入和室内环境。使用实时 PCR 测量新生儿完整脐血中的 IL-4 和 IFN-γ 水平。

结果

有 54 名孕妇患有过敏性疾病。与非过敏母亲相比，过敏母亲新生儿脐血中的 IL-4 和 IFN-γ 水平均较高（p<0.05）。过敏和非过敏母亲的室内环境和营养摄入没有差异，除了地毯使用情况。当细胞因子水平分为四等分时，较低的叶酸和维生素 B6 摄入与新生儿脐血中 IL-4 水平最高相关（p<0.05），而较高的叶酸和维生素 B6 摄入与新生儿脐血中 IFN-γ 水平最高相关。