Shi Jiachen, Yang Yunjia, Zhang Jing, Feng Yixing, Shao Bing
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing 100013, China.
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing 100013, China.
Ecotoxicol Environ Saf. 2016 Oct;132:339-44. doi: 10.1016/j.ecoenv.2016.05.025. Epub 2016 Jun 27.
Bisphenol AF (BPAF) is an analog of Bisphenol A (BPA) and is widely used as a raw material in the plastics industry. However, an understanding of the potential risks posed by BPAF in the aquatic environment is lacking. The bioconcentration factor (BCF) is a measure used to assess the secondary poisoning potential as well as risks to human health. In this work we measured the accumulation and elimination of BPAF in the whole-body and in liver, muscle and gonad tissues of zebrafish. BPAF uptake was relatively rapid with equilibrium concentrations reached after 24-72h of exposure. We observed gender differences both in whole-body and in tissue accumulation. Muscle was the primary BPAF storage tissue during the uptake phase in this study. In the elimination phase, BPAF concentrations declined rapidly during depuration, especially during the initial 2h, and the rate of elimination in males was faster than females from the whole-body and from tissues. The appearance of BPAF glucuronide (BPAF-G) at the start of the uptake phase indicated the rapid biotransformation of BPAF to BPAF-G in vivo. The high lipid content of female gonad could act to delay the diffusion of the xenobiotic within the body in a contaminated environment, but it also acts to delay xenobiotic elimination from the body.
双酚AF（BPAF）是双酚A（BPA）的类似物，在塑料工业中被广泛用作原材料。然而，目前对BPAF在水生环境中可能存在的风险尚缺乏了解。生物富集因子（BCF）是用于评估二次中毒可能性以及对人类健康风险的一种度量。在本研究中，我们测定了斑马鱼全身以及肝脏、肌肉和性腺组织中BPAF的蓄积和消除情况。BPAF的摄取相对较快，暴露24 - 72小时后达到平衡浓度。我们观察到全身和组织蓄积均存在性别差异。在本研究的摄取阶段，肌肉是主要的BPAF储存组织。在消除阶段，净化过程中BPAF浓度迅速下降，尤其是在最初的2小时内，并且从全身和组织来看，雄性的消除速率比雌性快。在摄取阶段开始时出现的BPAF葡萄糖醛酸苷（BPAF - G）表明BPAF在体内迅速生物转化为BPAF - G。在受污染环境中，雌性性腺的高脂质含量可能会延迟异生物质在体内的扩散，但它也会延迟异生物质从体内的消除。
