Jensen Hanna A, Mehta Jawahar L
a Department of Biomedical Engineering , University of Arkansas , Fayetteville , AR , USA.
b Department of Cardiology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Expert Rev Cardiovasc Ther. 2016 Sep;14(9):1021-33. doi: 10.1080/14779072.2016.1207527. Epub 2016 Jul 14.
Dysfunction of vessel endothelium is the first step in a complex and multi-faceted process that eventually leads to initiation of the plaque, formation of atherosclerotic lesions and their complications. The extremely fine-regulated endothelium is the gatekeeper of vascular health, and has been the target of a substantial amount of research.
This review examines some of the most common associations between therapies of cardiovascular disease and the endothelium, and summarizes the direction of research that may set the stage for one or more interventions targeted to repair damaged and/or dysfunctional endothelium. Expert commentary: Routine treatment of cardiovascular disease has frequently been shown to have a positive effect on the vascular endothelium. The big question - whether the impact is due to a direct pharmacological effect or whether the function of the endothelium improves as a result of a general improvement in the underlying disease state, is still largely unanswered.
血管内皮功能障碍是一个复杂多面过程的第一步，最终会导致斑块形成、动脉粥样硬化病变及其并发症。高度精细调节的内皮是血管健康的守门人，一直是大量研究的目标。
本综述探讨了心血管疾病治疗与内皮之间一些最常见的关联，并总结了可能为一项或多项旨在修复受损和/或功能失调内皮的干预措施奠定基础的研究方向。专家评论：心血管疾病的常规治疗经常被证明对血管内皮有积极作用。一个重大问题——这种影响是由于直接的药理作用，还是由于基础疾病状态的总体改善导致内皮功能改善，在很大程度上仍未得到解答。
